KLRA3 Antibody
| Code | Size | Price |
|---|
| PSI-4993-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-4993-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
KLRA3 Antibody: 5E6, Nk2, Nk-2, Ly49c, Nk2.1, NK-2.1, Ly-49c, Ly49C, Killer cell lectin-like receptor 3, 5E6
Application Note:
KLRA3 antibody can be used for detection of KLRA3 by Western blot at 2 μg/mL.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Background:
KLRA3 Antibody: KLRA3 (also known as Ly49C) is a member of the LY49 family of receptors in Natural Killer (NK) cells that bind to major histocompatibility complex (MHC) class 1. These proteins are classified as either activating or inhibitory receptors based on whether they possess an immunoreceptor tyrosine-based inhibitory motif (ITIM) in their cytoplasmic region (for inhibitory receptors), or an immunoreceptor tyrosine-based activation motif (ITAM) that transmits activating signals resulting in phosphorylation of several substrates. KLRA3 is thought to be an inhibitory receptor, recognizing peptide -receptive H-2Kb.
Background References:
- Gosselin P, Lusignan Y, Brennan J, et al. The NK2.1 receptor is encoded by Ly-49C and its expression is regulated by MHC class I alleles. Int. Immunol.1997; 533-40.
- Smith HR, Karlhofer FM, and Yokoyama WM. Ly-49 multigene family expressed by IL-2-activated NK cells. J. Immunol.1994; 153:1068-79.
- Brennan J, Mager D, Jefferies W, et al. Expression of different members of the Ly-49 gene family defines distinct natural killer cell subsets and cell adhesion properties. J. Exp. Med.1994; 180:2287-95.
- Su R-C, Kung SK, Silver ET, et al. Ly-49CB6 NK inhibitory receptor recognizes peptide-receptive H-2Kb. J. Immunol.1999; 163:5319-30.
Buffer:
KLRA3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
KLRA3 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of mouse KLRA3.
The immunogen is located within the last 50 amino acids of KLRA3.
The immunogen is located within the last 50 amino acids of KLRA3.
NCBI Gene ID #:
16634
NCBI Official Name:
killer cell lectin-like receptor, subfamily A, member 3
NCBI Official Symbol:
Klra3
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
AAI32525
Protein GI Number:
124376782
Purification:
KLRA3 Antibody is affinity chromatography purified via peptide column.
Research Area:
Immunology
SPECIFICITY:
This antibody may cross-react with other LY49 receptors.
Swissprot #:
Q64329
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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