CRMP1 Antibody
| Code | Size | Price |
|---|
| PSI-4983-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-4983-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
CRMP1 Antibody: DRP1, DRP-1, CRMP-1, DPYSL1, ULIP-3, ULIP3, Dihydropyrimidinase-related protein 1, Collapsin response mediator protein 1
Application Note:
CRMP1 antibody can be used for the detection of CRMP1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 5 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Background:
CRMP1 Antibody: Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain where they play major roles in axonal outgrowth, neurite differentiation, and apoptosis. Their continued expression in areas of high synaptic remodeling such as the cerebellum, hippocampus, and the olfactory system suggests that these proteins may also be involved in adult brain plasticity. CRMP-1 was initially identified as a dihydro-pyrimidinase expressed exclusively in brain; later studies have shown that it is involved with neurotrophin (NT) 3-induced neurite formation and outgrowth. CRMP-1 localization switches from axonal to somatodendritic when neurons reach functional maturity, suggesting that it is involved in early neuronal differentiation as well as in later processes related to the survival or death of the newly generated neurons.
Background References:
- Charrier E, Reibel S, Rogemond V, et al. Collapsin response mediator proteins (CRMPs): involvement in nervous system development and adult neurodegenerative disorders. Mol. Neurobiol.2003; 28:51-64.
- Cameron HA and McKay RD. Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J. Comp. Neurol.2001; 435:406-417.
- Hamajima N, Matsuda K, Sakata S, et al. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. Gene.1996; 180:157-63.
- Quach TT, Duchemin A-M, Rogemond V, et al. Involvement of collapsin response mediator proteins in the neurite extension induced by neurotrophins in dorsal root ganglion neurons. Mol. Cell. Neurosci.2004; 25:433-43.
Buffer:
CRMP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
CRMP1 antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human CRMP1.
The immunogen is located within amino acids 90 - 140 of CRMP1.
The immunogen is located within amino acids 90 - 140 of CRMP1.
NCBI Gene ID #:
1400
NCBI Official Name:
collapsin response mediator protein 1
NCBI Official Symbol:
CRMP1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_001014809
Protein GI Number:
14043246
Purification:
CRMP1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
SPECIFICITY:
This antibody is expected to recognize only the longest isoform of CRMP-1.
Swissprot #:
Q14194
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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