ZIP10 Antibody
| Code | Size | Price |
|---|
| PSI-4991-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-4991-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
ZIP10 Antibody:
Application Note:
ZIP10 antibody can be used for detection of ZIP10 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Background:
ZIP10 Antibody: ZIP10, also known as Slc39A10, is a widely expressed zinc transporter with nine transmembrane domains. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP10 mRNA was found to be significantly decreased in the intestines and kidneys of hypothyroid rats and increased in those of hyperthyroid rats, indicating that ZIP10 is positively regulated by thyroid hormones. ZIP10 mRNA was also found to be upregulated in invasive and metastatic breast cancer and cell lines, suggesting that ZIP10 could serve as a possible marker for the metastatic phenotype and possibly a target for novel treatment strategies. At least three isoforms of ZIP10 are known to exist.
Background References:
- Kaler P and Prasad R. Molecular cloning and functional characterization of novel transporter rZip10 (Slc39a10) involved in zinc uptake across renal brush-border membrane. Am. J. Renal Physiol.2007; 292:F217-29.
- Taylor KM and Nicohlson RI. The LZT proteins; the LIV-1 subfamily of zinc transporters. Biochim. Biophys. Acta.2003; 1611:16-30.
- Pawan K, Neeraj S, Sandeep K, et al. Upregulation of Slc39a10 gene expression in response to thyroid hormones in intestine and kidney. Biochim. Biophys. Acta.2007; 1769:117-23.
- Kagara N, Tanaka N, Noguchi S, et al. Zinc and its transporter ZIP10 are involved in invasive behavior of breast cancer cells. Cancer Sci.2007; 98:692-7.
Buffer:
ZIP10 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
ZIP10 antibody was raised against a 17 amino acid synthetic peptide near the center of the human ZIP10.
The immunogen is located within amino acids 490 - 540 of ZIP10.
The immunogen is located within amino acids 490 - 540 of ZIP10.
NCBI Gene ID #:
363229
NCBI Official Name:
solute carrier family 39 (zinc transporter), member 10
NCBI Official Symbol:
Slc39a10
NCBI Organism:
Rattus norvegicus
Physical State:
Liquid
Protein Accession #:
EAW70116
Protein GI Number:
149046180
Purification:
ZIP10 Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
SPECIFICITY:
This antibody will not cross-react with the zinc transporter ZIP11.
Swissprot #:
Q9ULF5
User NOte:
Optimal dilutions for each application to be determined by the researcher.
Related Products
| Product Name | Product Code | Supplier | ZIP10 Peptide | PSI-4991P | ProSci | Summary Details | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|