TTBK1 Antibody
| Code | Size | Price |
|---|
| PSI-5013-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5013-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
TTBK1 Antibody: BDTK, BDTK, KIAA1855, Tau-tubulin kinase 1, Brain-derived tau kinase
Application Note:
TTBK1 antibody can be used for detection of TTBK1 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
TTBK1 Antibody: Tau tubulin kinase (TTBK1) belongs to the casein kinase 1 superfamily and is involved in the phosphorylation of specific serine/threonine residues in paired helical filaments of the tau protein. It is specifically expressed in the brain and induces tau aggregation in human neuronal cells in a dose-dependent manner. TTBK1 levels have been found to be upregulated in the brains of Alzheimer's disease (AD) patients, and mice expressing human TTBK1 protein showed significant age-dependent memory impairment. These mice displayed increased levels of the CDK5 activators p25 and p35, and reduced levels of the NMDA receptor types 2B and 2D, suggesting that TTBK1 may play a role in memory dysfunction in AD patients.
Background References:
- Sato S, Cerny RL, Bueschner JL, et al. Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation. J. Neurochem. 2006; 98:1573-84.
- Sato S, Xu J, Okuyama S, et al. Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. J. Neurosci. 2008; 28:14511-21.
Buffer:
TTBK1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
TTBK1 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human TTBK1.
The immunogen is located within amino acids 1190 - 1240 of TTBK1.
The immunogen is located within amino acids 1190 - 1240 of TTBK1.
NCBI Gene ID #:
84630
NCBI Official Name:
tau tubulin kinase 1
NCBI Official Symbol:
TTBK1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 145, 151 kDa
Observed: 140 kDa
Observed: 140 kDa
Protein Accession #:
Q5TCY1
Protein GI Number:
97203020
Purification:
TTBK1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
SPECIFICITY:
Multiple isoforms of TTBK1 are known to exist. This antibody is predicted to not cross-react with TTBK2.
Swissprot #:
Q5TCY1
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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