TMEM18 Antibody
| Code | Size | Price |
|---|
| PSI-5043-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5043-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
TMEM18 Antibody: Transmembrane protein 18
Application Note:
TMEM18 antibody can be used for detection of TMEM18 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Background:
TMEM18 Antibody: Recent studies have examined how overexpression of certain genes enhances the tropism of neural stem cells (NSCs) for gliomas. Overexpression of Transmembrane protein 18 (TMEM18) provides NSCs and neural precursors an increased migration capacity towards glioblastoma cells in vitro and in the rat brain, while functional inactivation of the gene resulted in an almost complete loss of migration activity, suggesting that TMEM18 could be a potential target in NSC-based glioma therapy. Other recent results suggest that among others, the TMEM18 loci is associated with higher than normal body mass index (BMI) and obesity, indicating there may be a CNS-related role in predisposition to obesity. Multiple isoforms of TMEM18 are known to exist.
Background References:
- Jurvansuu J, Zhao Y, Leung DS, et al. Transmembrane protein 18 enhances the tropism of neural stem cells for glioma cells. Cancer Res.2008; 68:4614-22.
- Willer CJ, Speliotes EK, Loos RJ, et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat. Genet.2009; 41:25-34.
- Renstrom F, Payne F, Nordstrom A, et al. Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden. Human Mol. Gen.2009; 18:1489-96.
Buffer:
TMEM18 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
TMEM18 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human TMEM18.
The immunogen is located within the last 50 amino acids of TMEM18.
The immunogen is located within the last 50 amino acids of TMEM18.
NCBI Gene ID #:
129787
NCBI Official Name:
transmembrane protein 18
NCBI Official Symbol:
TMEM18
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
Q96B42
Protein GI Number:
119621502
Purification:
TMEM18 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
Swissprot #:
Q96B42
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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