FNIP2 Antibody

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ProSci
Product Code: PSI-5045
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-5045-0.02mg0.02mg£150.00
Quantity:
PSI-5045-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Images

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Western blot analysis of FNIP2 in rat skeletal muscle lysate with FNIP2 antibody at (A) 1 and (B) 2 μg/mL.
2 / 2
Immunohistochemistry of FNIP2 in mouse skeletal muscle tissue with FNIP2 antibody at 5 μg/mL.
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Western blot analysis of FNIP2 in rat skeletal muscle lysate with FNIP2 antibody at (A) 1 and (B) 2 μg/mL.
Immunohistochemistry of FNIP2 in mouse skeletal muscle tissue with FNIP2 antibody at 5 μg/mL.

Documents

Further Information

Additional Names:
FNIP2 Antibody: FNIPL, MAPO1, FNIPL, KIAA1450, Folliculin-interacting protein 2, FNIP1-like protein
Application Note:
FNIP2 antibody can be used for detection of FNIP2 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.

Antibody validated: Western Blot in rat samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.
Background:
FNIP2 Antibody: FNIP2 is the second protein found to interact with folliculin, the product of the Birt-Hogg-Dube (BHD) gene. Folliculin is thought to act as a tumor suppressor as mutations or loss of heterozygosity in this gene are associated with BHD syndrome-related renal tumors. Folliculin and FNIP1, a protein that shares 49% identity to FNIP2, bind to AMPK, an important energy sensor in cells that negatively regulates the mammalian target of rapamycin (mTOR), a protein that is thought to be the master switch for cell growth and proliferation. FNIP1 and FNIP2 are able to form homo- and heteromeric multimers, suggesting these proteins may have a functional relationship.
Background References:
  • Hasumi H, Baba M, Hong S-B, et al. Identification and characterization of a novel folliculin-interacting protein FNIP2. Gene2008; 415:60-7.
  • Takagi Y, Kobayashi T, Shiono M, et al. Interaction of folliculin (Birt-Hogg-Dube gene product) with novel Fnip1-like (FnipL/Fnip2) protein. Oncogene2008; 27:5339-47.
  • Vocke CD, Yang Y, Pavlovich CP, et al. High frequency of somatic frameshift BHD mutations in Birt-Hogg-Dube-associated renal tumors. J. Natl. Cancer Inst.2005; 97:931-5.
  • Baba M, Hong SB, Sharma M, et al. Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. Proc. Natl. Acad. Sci. USA2006; 103:15552-7.
Buffer:
FNIP2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
FNIP2 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human FNIP2.

The immunogen is located within amino acids 860 - 910 of FNIP2.
NCBI Gene ID #:
57600
NCBI Official Name:
folliculin interacting protein 2
NCBI Official Symbol:
FNIP2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_065891
Protein GI Number:
154689769
Purification:
FNIP2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
SPECIFICITY:
Multiple isoforms of FNIP2 are known to exist. This antibody is predicted to not cross-react with FNIP1.
Swissprot #:
Q9P278
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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