MTCH2 Antibody

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ProSci
Product Code: PSI-5063
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-5063-0.02mg0.02mg£150.00
Quantity:
PSI-5063-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Images

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Western blot analysis of MTCH2 in 293 cell lysate with MTCH2 antibody at 1 μg/mL.
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Immunohistochemistry of MTCH2 in mouse kidney tissue with MTCH2 antibody at 5 μg/mL.
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Immunofluorescence of MTCH2 in Mouse Kidney cells with MTCH2 antibody at 20 μg/mL.
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Western blot analysis of MTCH2 in 293 cell lysate with MTCH2 antibody at 1 μg/mL.
Immunohistochemistry of MTCH2 in mouse kidney tissue with MTCH2 antibody at 5 μg/mL.
Immunofluorescence of MTCH2 in Mouse Kidney cells with MTCH2 antibody at 20 μg/mL.

Documents

Further Information

Additional Names:
MTCH2 Antibody: HSPC032, 2310034D24Rik, 4930539J07Rik, Mitochondrial carrier homolog 2
Application Note:
MTCH2 antibody can be used for detection of MTCH2 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Background:
MTCH2 Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. MTCH2 is a member of the mitochondrial carrier protein family that catalyze the exchange of substrates across the inner mitochondrial membrane and is targeted by Bid, a pro-apoptotic Bcl-2 family member, in response to apoptotic signals, suggesting that MTCH2 may play a key role in the mitochondrial apoptosis pathway.
Background References:
  • Lockshin RA, Osborne B, and Zakeri Z. Cell death in the third millennium. Cell Death Differ.2000; 7:2-7.
  • Cory S, Huang DCS, and Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene2003; 22:8590-607.
  • Heiser D, Labi V, Erlacher M, et al. The Bcl-2 protein family and its role in the development of neoplastic disease. Exp. Geron.2004; 39:1125-35.
  • Grinberg M, Schwarz M, Zaltsman Y, et al. Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha. Mol. Cell. Biol.2005; 25:4579-90.
Buffer:
MTCH2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (75%)
Immunogen:
MTCH2 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human MTCH2.

The immunogen is located within amino acids 80 - 130 of MTCH2.
NCBI Gene ID #:
56428
NCBI Official Name:
mitochondrial carrier homolog 2 (C. elegans)
NCBI Official Symbol:
Mtch2
NCBI Organism:
Mus musculus
Physical State:
Liquid
Protein Accession #:
NP_055157
Protein GI Number:
5815347
Purification:
MTCH2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Apoptosis
Swissprot #:
Q791V5
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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