PCDH18 Antibody
| Code | Size | Price |
|---|
| PSI-5081-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5081-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
PCDH18 Antibody: PCDH68L, KIAA1562, Protocadherin-18
Application Note:
PCDH18 antibody can be used for detection of PCDH18 by Western blot at 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Background:
PCDH18 Antibody: Protocadherins comprise the largest group within the cadherin family of calcium-dependent cell-cell adhesion molecules. Protocadherin 18 (PCDH18) was initially identified through screening of human and mouse ESTs using conserved cytoplasmic domain motifs. Tissue screening revealed PCDH18 broad expression in tissues such as brain, liver, heart, kidney, lung, and trachea. PCDH18 expression is also temporally and spatially regulated in the mouse embryonic brain and interacts with Disabled-1, an intracellular adapter protein involved in neuronal migration and cell positioning during mammalian brain development. PCDH18 was also found to be expressed in the developing zebrafish neural tube and central nervous system, lending support to the hypothesis that PCDH18 may play a role during brain development.
Background References:
- Frank M and Kemler R. Protocadherins. Curr. Opin. Cell Biol.2002; 14:557-62.
- Wolverton T and Lalande M. Identification and characterization of three members of a novel subclass of protocadherins. Genomics2001; 76:66-72.
- Homayouni R, Rice DS, and Curran T. Disabled-1 interacts with a novel developmentally regulated protocadherin. Biochem. Biophys. Res. Commun.2001; 289:539-47.
- Kubota F, Murakami T, Tajika Y, et al. Expression of protocadherin 18 in the CNS and pharyngeal arches of zebrafish embryos. Int. J. Dev. Biol.2008; 52:397-405.
Buffer:
PCDH18 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (95%)
Immunogen:
PCDH18 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human PCDH18.
The immunogen is located within amino acids 50 - 100 of PCDH18.
The immunogen is located within amino acids 50 - 100 of PCDH18.
NCBI Gene ID #:
54510
NCBI Official Name:
protocadherin 18
NCBI Official Symbol:
PCDH18
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_061908
Protein GI Number:
14589929
Purification:
PCDH18 Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
SPECIFICITY:
At least three isoforms of PCDH18 are known to exist. This antibody is predicted to not cross-react with PCDH12.
Swissprot #:
Q9HCL0
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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