MATN1 Antibody
| Code | Size | Price |
|---|
| PSI-5139-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5139-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
MATN1 Antibody: CMP, CRTM, CMP, Cartilage matrix protein, Matrilin-1
Application Note:
MATN1 antibody can be used for detection of MATN1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Background:
MATN1 Antibody: Matrilins (MATNs) are a family of non-collagenous extra-cellular matrix (ECM) proteins consisting of four known members that have been proposed to play key roles in modulating cellular phenotypes during chondrogenesis of mesenchymal stem cells (MSCs). MATN1 and MATN3 are expressed specifically in cartilage and are among the most up-regulated ECM proteins during chondrogenesis. MATN1 is composed of two Willebrand Factor A (vWFA) domains separated by one EGF-like domain, whereas MATN3 is composed of a single N-terminal vWFA domain followed by four epidermal growth factor (EGF) repeats and a coiled-coil domain. MATN1 or MATN3 may play a role in modulating chondrogenesis during the chondrocyte differentiation process. Mutations of this gene have been associated with variety of inherited chondrodysplasias. Recent studies show that the MATN1 promoter region was associated with both susceptibility and disease progression in Adolescent idiopathic scoliosis.
Background References:
- Pei M, Luo J, and Chen Q. Enhancing and maintaining matrilins. Osteoarthritis Cartilage2008; 16:1110-7.
- Frank S, Schulthess T, Landwehr R, et al. Characterization of the matrilin coiled-coil domains reveals seven novel isoforms. J. Biol. Chem.2002; 277:19071-9.
- Chen Q, Johnson DM, Haudenschild DR, et al. Progression and recapitulation of the chondrocyte differentiation program: cartilage matrix protein is a marker for cartilage maturation. Dev. Biol.1995; 172:293-306.
- Stokes DG, Liu G, Coimbra IB, et al. Assessment of the gene expression profile of differentiated and dedifferentiated human fetal chondrocytes by microarray analysis. Arthritis Rheum2002; 46:404-19.
Buffer:
MATN1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
MATN1 antibody was raised against a 12 amino acid synthetic peptide from near the amino terminus of human MATN1.
The immunogen is located within amino acids 120 - 170 of MATN1.
The immunogen is located within amino acids 120 - 170 of MATN1.
NCBI Gene ID #:
4146
NCBI Official Name:
matrilin 1, cartilage matrix protein
NCBI Official Symbol:
MATN1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_002370
Protein GI Number:
4505111
Purification:
MATN1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
Swissprot #:
P21941
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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