RUNX1 Antibody
| Code | Size | Price |
|---|
| PSI-5149-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5149-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
RUNX1 Antibody: AML1, CBFA2, EVI-1, AMLCR1, PEBP2aB, AML1-EVI-1, AML1, Runt-related transcription factor 1, Acute myeloid leukemia 1 protein, CBF-alpha-2
Application Note:
RUNX1 antibody can be used for detection of RUNX1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
RUNX1 Antibody: RUNX1 is one of three mammalian RUNX genes that control multiple aspects of embryonic development and are responsible for the pathogenesis of many human diseases. RUNX1 plays major roles in the development of nociceptive sensory neurons in addition to hematopoietic stem cells (HSC) with the exception of the erythroid lineage. During development, Notch signals mediate RUNX1 induction with SCL/GATA/Ets factors, and Wnt signals potentially cooperate with RUNX1 to facilitate adult HSC expansion via cooperative induction of cyclin D, cdk4, and other cell cycle regulators. In turn, RUNX1 regulates cell cycle transitions dependent on functional/physical interactions with other proteins such as HDAC1 and -3, mSin3A, p300, SMAD proteins, and LEF/TCF.
Background References:
- Lund AH and van Lohuizen M. RUNX: a trilogy of cancer genes. Cancer Cell2002; 1:213-5.
- Inoue K, Shiga T, and Ito Y. Runx transcription factors in neuronal development. Neur. Dev.2008; 3:20.
- North TE, Stacy T, Matheny CJ, et al. Runx1 is expressed in adult mouse hematopoietic stem cells and differentiating myeloid and lymphoid cells, but not in maturing erythroid cells. Stem Cells2004; 22:158-68.
- Lee TI, Jenner RG, Boyer LA. Control of developmental regulators by Polycomb in human embryonic stem cells. Cell2006; 125:301-13.
Buffer:
RUNX1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
RUNX1 antibody was raised against a 16 amino acid synthetic peptide from near the center of human RUNX1.
The immunogen is located within amino acids 160 - 210 of RUNX1.
The immunogen is located within amino acids 160 - 210 of RUNX1.
NCBI Gene ID #:
861
NCBI Official Name:
runt-related transcription factor 1
NCBI Official Symbol:
RUNX1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
AAI36381
Protein GI Number:
223459612
Purification:
RUNX1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
Swissprot #:
Q01196
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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