MC4R Antibody
| Code | Size | Price |
|---|
| PSI-5199-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5199-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
MC4R Antibody: Melanocortin receptor 4, MC4-R
Application Note:
MC4R antibody can be used for detection of MC4R by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
MC4R Antibody: The melanocortin-4 receptor (MC4R) is a member of the superfamily of seven transmembrane G-protein coupled receptors that are involved in multiple signal transduction pathways including the cAMP and MAPK signaling pathways. It is thought that the melanocortin system modulates energy expenditure and insulin sensitivity; activation of the MC4R results in the inhibition of c-Jun N-terminal kinase (JNK) activity and promotes insulin signaling. MC4R-null mice display maturity onset obesity characterized by hyperphagia, increased adiposity, hyperinsulinaemia and hyperleptinaemia, suggesting that like other obesity-linked genes such as FTO, PTER, and NPC1, MC4R is a potential candidate target for the treatment of obesity.
Background References:
- Gantz I, Miwa H, Konda Y, et al. Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. J. Biol. Chem.1993; 268:15174-9.
- Vongs A, Lynn NM, and Rosenblum CI. Activation of MAP kinase by MC4-R through PI3 kinase. Regul. Pept.2004; 120:113-8.
- Cone H. Anatomy and regulation of the central melanocortin system. Nat. Neurosci.2005; 8:571-8.
- Chai B, Li J-Y, Zhang W, et al. Melanocartin-4 receptor activation inhibits c-Jun N-terminal kinase activity and promotes insulin signaling. Peptides2009; 30:1098-10
Buffer:
MC4R Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Pig: (79%)
Immunogen:
MC4R antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human MC4R.
The immunogen is located within the first 50 amino acids of MC4R.
The immunogen is located within the first 50 amino acids of MC4R.
NCBI Gene ID #:
4160
NCBI Official Name:
melanocortin 4 receptor
NCBI Official Symbol:
MC4R
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_005903
Protein GI Number:
119508433
Purification:
MC4R Antibody is affinity chromatography purified via peptide column.
Research Area:
Obesity
Swissprot #:
P32245
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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