UCMA Antibody
| Code | Size | Price |
|---|
| PSI-5211-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5211-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
UCMA Antibody: GRP, C10orf49, Unique cartilage matrix-associated protein, Gla-rich protein, Ucma-C
Application Note:
UCMA antibody can be used for detection of UCMA by Western blot at 2.5 - 5 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
UCMA Antibody: UCMA is a secreted cartilage-specific protein that was discovered in a screen for differentially expressed genes in retinoic acid-treated mouse chondrocytes. It was also identified in a human chondrocyte EST screen for candidate genes of skeletal dysplasias. UCMA expression is thought to parallel that of collagen II with its expression decreasing with maturation chrondrocytes mature. UCMA is processed by a furin-like protease into two fragments, an amino-terminal fragment and a carboxy-terminal fragment (UCMA-C). Application of recombinant UCMA-C to primary osteoblasts, mesenchymal stem cells, and MC3T3-E1 pre-osteoblasts interferes with their osteogenic differentiation, but does not affect expression of chondrocyte-specific genes or chondrocyte proliferation, suggesting that UCMA may be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells. At least two isoforms of UCMA are known to exist.
Background References:
- Surmann-Schmitt C, Dietz U, Kireva T, et al. Ucma, a novel secreted cartilage-specific protein with implications in osteogenesis. J. Biol. Chem.2008; 283:7082-93.
- Tagariello A, Luther J, Streiter M, et al. Ucma - a noel secreted factor represents a highly specific marker for distal chondrocytes. Matrix Biol.2008; 27:3-11.
Buffer:
UCMA Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat: (81%)
Immunogen:
UCMA antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human UCMA.
The immunogen is located within the last 50 amino acids of UCMA.
The immunogen is located within the last 50 amino acids of UCMA.
NCBI Gene ID #:
221044
NCBI Official Name:
upper zone of growth plate and cartilage matrix associated
NCBI Official Symbol:
UCMA
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 15 kDa
Observed: 19 kDa
Observed: 19 kDa
Protein Accession #:
NP_660357
Protein GI Number:
50400088
Purification:
UCMA Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
Swissprot #:
Q8WVF2
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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