CCDC134 Antibody
| Code | Size | Price |
|---|
| PSI-5265-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5265-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
CCDC134 Antibody: dJ821D11.3, Coiled-coil domain-containing protein 134
Application Note:
CCDC134 antibody can be used for detection of CCDC134 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
CCDC134 Antibody: The coiled-coil domain is a common protein motif that is often involved in protein oligomerization and is found in proteins such as transcription factors and intermediate filaments. One such protein is CCDC134, a recently identified secretory protein that has been found to inhibit the transcriptional activity of the Elk1 protein. Overexpression CCDC134 also inhibited the phosphorylation of Erk and JNK/SAPK but not p38 MAPK, while specific siRNA against CCDC134 activated Elk1 transcriptional activity and the phosphorylation of Erk and JNK/SAPK, suggesting a potential inhibiting role of CCDC134 in MAPK-mediated Elk1 transcription. CCDC134 is widely expressing in normal adult tissues, tumors, and cell lines.
Background References:
- Steinmetz MO, Jelesarov I, Matousek WM, et al. Molecular basis of coiled-coil formation. Proc. Natl. Acad. Sci. USA2007; 104:7062-7.
- Huang J, Shi T, Ma T, et al. CCDC134, a novel secretory protein, inhibits activation of ERK and JNK, but not p38 MAPK. Cell. Mol. Life Sci.2008; 65:338-49.
Buffer:
CCDC134 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
CCDC134 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human CCDC134.
The immunogen is located within the first 50 amino acids of CCDC134.
The immunogen is located within the first 50 amino acids of CCDC134.
NCBI Gene ID #:
79879
NCBI Official Name:
coiled-coil domain containing 134
NCBI Official Symbol:
CCDC134
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_079097
Protein GI Number:
13376216
Purification:
CCDC134 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer
Swissprot #:
Q9H6E4
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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