Seasonal H1N1 Nucleocapsid Protein Antibody

Contact us
ProSci
Product Code: PSI-5361
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-5361-0.02mg0.02mg£150.00
Quantity:
PSI-5361-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Application: Enzyme-Linked Immunosorbent Assay (ELISA)

Images

1 / 1
ELISA results using Seasonal H1N1 Nucleocapsid Protein antibody at 1 μg/mL and the blocking and corresponding peptides at 60, 10, 2 and 0 ng/mL.
❮❯

ELISA results using Seasonal H1N1 Nucleocapsid Protein antibody at 1 μg/mL and the blocking and corresponding peptides at 60, 10, 2 and 0 ng/mL.

Documents

Further Information

Additional Names:
Seasonal H1N1 Nucleocapsid Protein Antibody:
Application Note:
NP antibody can be used for the detection of the NP protein from the H1N1 strain of Seasonal Influenza A in ELISA.
Background:
Seasonal H1N1 Nucleocapsid Protein Antibody: Influenza A virus is a major public health threat, killing more than 30, 000 people per year in the USA. In early 2009, a novel swine-origin influenza A (H1N1) virus (S-OIV) was identified in specimens obtained from patients in Mexico and the United States. The influenza A virus polymerase transcribes and replicates eight virion RNA (vRNA) segments, among which the nucleocapsid protein (NP), thought to control whether mRNA or cRNA is produced. The nucleoprotein (NP), which has multiple functions during the virus life cycle, possesses regions that are highly conserved among influenza A, B, and C viruses. It was recently found several NP mutations that affected the efficient incorporation of multiple viral-RNA (vRNA) segments into progeny virions even though a single vRNA segment was incorporated efficiently. This indicates that the respective conserved amino acids in NP may be critical for the assembly and/or incorporation of sets of eight vRNA segments.
Background References:
  • Thompson WW, Shay DK, Weintraub, et al. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA2003; 289:179-186.
  • Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team, Dawood FS, Jain S, et al. Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N. Engl. J. Med.2009; 360:2605-15.
  • Li Z, Watanabe T, Hatta M, et al. Mutational analysis of conserved amino acids in the influenza A virus nucleoprotein. J. Virol.2009; 83:4153-62.
  • Newcomb LL, Kuo RL, Ye Q, et al. Interaction of the influenza a virus nucleocapsid protein with the viral RNA polymerase potentiates unprimed viral RNA replication. J. Virol.2009; 83:29-36.
Buffer:
Seasonal H1N1 Nucleocapsid Protein Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
NP antibody was raised against a synthetic peptide from the seasonal H1N1 NP protein.

The immunogen is located within amino acids 350 - 400 of Seasonal H1N1 Nucleocapsid Protein.
NCBI Official Name:
nucleocapsid protein
NCBI Official Symbol:
NP
NCBI Organism:
Influenza A virus (A/Brisbane/97/2007(H1N1))
Physical State:
Liquid
Protein Accession #:
AFK14863
Protein GI Number:
260593857
Purification:
Seasonal H1N1 Nucleocapsid Protein Antibody is affinity chromatography purified via peptide column.
Research Area:
Infectious Disease
SPECIFICITY:
This antibody is specific for the seasonal H1N1 influenza NP and will not recognize the corresponding NP sequence from the swine-origin H1N1 influenza (A/California/14/2009 (H1N1)).
Swissprot #:
I3QSJ8
User NOte:
Optimal dilutions for each application to be determined by the researcher.

Related Products

Product NameProduct CodeSupplier 
Seasonal H1N1 Nucleocapsid Protein PeptidePSI-5361PProSci Summary Details