PALB2 Antibody
| Code | Size | Price |
|---|
| PSI-5275-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5275-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
PALB2 Antibody: FANCN, PNCA3, FANCN, Partner and localizer of BRCA2
Application Note:
PALB2 antibody can be used for detection of PALB2 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
PALB2 Antibody: The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51network may allow predictions to be made of the responsiveness of a particular tumor to therapeutic treatments.
Background References:
- Greenberg RA. Recognition of DNA double strand breaks by the BRCA1 tumor suppressor network. Chromosoma 2008; 117:305-17.
- Xia B, Sheng Q, Nakanishi K, et al. Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB. Mol. Cell 2007; 22:719-29.
- Rahman N, Seal S, Thompson D, et al. PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene. Nat. Genet. 2007; 39:165-7.
- Zhang F, Fan Q, Ren K, et al. PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2. Mol. Cancer. Res. 2009; 7:1110-8.
Buffer:
PALB2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
PALB2 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human PALB2.
The immunogen is located within amino acids 940 - 990 of PALB2.
The immunogen is located within amino acids 940 - 990 of PALB2.
NCBI Gene ID #:
79728
NCBI Official Name:
partner and localizer of BRCA2
NCBI Official Symbol:
PALB2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 65, 100, 130 kDa
Observed: 140 kDa
Observed: 140 kDa
Protein Accession #:
Q86YC2
Protein GI Number:
74727919
Purification:
PALB2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer
SPECIFICITY:
At least four isoforms of PALB2 are known to exist; this antibody will detect all four isoforms.
Swissprot #:
Q86YC2
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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