SYPL1 Antibody
| Code | Size | Price |
|---|
| PSI-5285-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5285-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
SYPL1 Antibody: SYPL, H-SP1, SYPL, Synaptophysin-like protein 1, Pantophysin
Application Note:
SYPL1 antibody can be used for detection of SYPL1 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
SYPL1 Antibody: The synaptophysin-like protein 1, also known as pantophysin, is a homolog of the neuroendocrine-specific protein synaptophysin, with the highest level of homology across its four transmembrane domains. Unlike synaptophysin however, SYPL1 is ubiquitously expressed and found in small cytoplasmic transport vesicles regardless of their content. SYPL1 is thought to play a multifunctional role in vesicle biogenesis and transport and is a component of adipocyte transport vesicles, and thus may be involved in adipocyte secretion. SYPL1 also interacts with vesicle-associated membrane protein 2 (VAMP-2) in adipocytes and associates with GLUT4-containing vesicles.
Background References:
- Haass NK, Kartenbeck MA, and Leube RE. Pantophysin is a ubiquitously expressed synaptophysin homologue and defines constitutive transport vesicles. J. Cell Biol.1996; 134:731-46.
- Brooks CC, Scherer PE, Cleveland K, et al. Pantophysin is a phosphoprotein component of adipocyte transport vesicles and associates with GLUT4-containin vesicles. J. Biol. Chem.2000; 275:2029-36.
- Bradley RL, Cleveland KA, and Cheatham B. The adipocyte as a secretory organ: mechanism of vesicle transport and secretory pathways. Recent Prog. Horm. Res.2001; 56:329-58.
Buffer:
SYPL1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
SYPL1 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human SYPL1.
The immunogen is located within the first 50 amino acids of SYPL1.
The immunogen is located within the first 50 amino acids of SYPL1.
NCBI Gene ID #:
6856
NCBI Official Name:
synaptophysin-like 1
NCBI Official Symbol:
SYPL1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_006745
Protein GI Number:
5803185
Purification:
SYPL1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
SPECIFICITY:
This antibody will not recognize synaptophysin of SYPL2. Two isoforms of SYPL1 are known to exist; this antibody will only recognize the longer isoform.
Swissprot #:
Q16563
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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