JMJD1B Antibody
| Code | Size | Price |
|---|
| PSI-5369-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5369-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
JMJD1B Antibody: 5qNCA, NET22, C5orf7, JMJD1B, JHDM2B, KIAA1082, Lysine-specific demethylase 3B, JmjC domain-containing histone demethylation protein 2B
Application Note:
JMJD1B antibody can be used for detection of JMJD1B by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Background:
JMJD1B Antibody: The jumonji domain containing 1B protein (JMJD1B) was originally discovered as a candidate for the myeloid leukemia tumor suppressor gene. Besides CD34+ cells and acute myeloid leukemia (AML) cell lines, JMJD1B mRNA is highly expressed in liver, heart, kidney, skeletal muscle, and placenta tissues. The JMJD1B gene is localized to a region of chromosome 5q31, which is frequently deleted in myeloid leukemias and myelodysplasias and expression of JMJD1B in a del(5q) cell line results in suppression of clonogenic growth suggesting that JMJD1B may function as a tumor suppressor. In contrast, JMJD1B gene copy number and mRNA expression level was increased in several non-small cell lung cancers indicating that the role of JMJD1B in cancer formation and progression is more complex than originally postulated. At least three isoforms of JMJD1B are known to exist.
Background References:
- Lai F, Godley LA, Fernald AA, et al. cDNA cloning and genomic structure of three genes localized to human chromosome band 5q31 encoding potential nuclear proteins. Genomics2000; 70:123-30.
- Hu Z, Gomes I, Horrigan SK, et al. A novel nuclear protein, 5qNCA (LOC51780) is a candidate for the myeloid leukemia tumor suppressor gene on chromosome band q31. Oncogene2001; 20:6946-54.
- Baik S-H, Jee B-K, Choi J-S, et al. DNA profiling by array comparative genomic hybridization (CGH) of peripheral blood mononuclear cells (PBMC) and tumor tissue cell in non-small cell lung cancer (NSCLC). Mol. Biol. Rep.2009; 36:1767-78.
Buffer:
JMJD1B Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
JMJD1B antibody was raised against a 20 amino acid synthetic peptide from near the center of human JMJD1B.
The immunogen is located within amino acids 1050 - 1100 of JMJD1B.
The immunogen is located within amino acids 1050 - 1100 of JMJD1B.
NCBI Gene ID #:
51780
NCBI Official Name:
lysine (K)-specific demethylase 3B
NCBI Official Symbol:
KDM3B
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
EAW62141
Protein GI Number:
119582545
Purification:
JMJD1B Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer
SPECIFICITY:
This antibody will not cross-react with JMJD1A or JMJD1C.
Swissprot #:
Q7LBC6
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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