AGTR2 Antibody
| Code | Size | Price |
|---|
| PSI-5393-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5393-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
AGTR2 Antibody: AT2, ATGR2, MRX88, Type-2 angiotensin II receptor, Angiotensin II type-2 receptor, AT2
Application Note:
AGTR2 antibody can be used for detection of AGTR2 by Western blot at 0.5 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunocytochemistry start at 5 μg/mL. For immunofluorescence start at 1 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in rat samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in rat samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
AGTR2 Antibody: Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion that acts through at least two types of receptors, AGTR1 and AGTR2. It is an important effector controlling blood pressure and volume in the cardiovascular system and plays a major role in the development of the mammalian kidney and urinary tract. Like AGTR1, AGTR2 is a seven transmembrane G protein-coupled receptor (GPCR), but AGTR2 does not demonstrate most of the classic features of GPCR signaling. AGTR2 is involved in a wide range of activities, including the induction of neurite outgrowth and the inhibition of cellular proliferation, in addition to the known function of mediation of vasoconstriction.
Background References:
- Mottl AK, Shoham DA, and North KE. Angiotensin II type 1 receptor polymorphisms and susceptibility to hypertension: A HuGE review. Gen. in Med. 2008; 10:560-574.
- Miyazaki Y and Ichikawa I. Role of the angiotensin receptor in the development of the mammalian kidney and urinary tract. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 2001; 128:89-97.
- Laflamme L, Gasparo M, Gallo JM, et al. Angiotensin II induction of neurite outgrowth by AT2 receptors in NG108-15 cells. Effect counteracted by the AT1 receptors. J. Biol. Chem.1996; 271:22729-35.
- Stoll M, Steckelings UM, Paul M, et al. The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells. J. Clin. Invest. 1995; 95:651-7.
Buffer:
AGTR2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Sheep: (100%)
Immunogen:
AGTR2 antibody was raised against a 16 amino acid synthetic peptide from near the center of human AGTR2.
The immunogen is located within amino acids 220 - 270 of AGTR2.
The immunogen is located within amino acids 220 - 270 of AGTR2.
NCBI Gene ID #:
186
NCBI Official Name:
angiotensin II receptor, type 2
NCBI Official Symbol:
AGTR2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 40 kDa
Observed: 36 kDa
Observed: 36 kDa
Protein Accession #:
AAS45437
Protein GI Number:
42766665
Purification:
AGTR2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
Swissprot #:
P50052
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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