RUSC1 Antibody
| Code | Size | Price |
|---|
| PSI-5411-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5411-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
RUSC1 Antibody: NESCA, NESCA, RUN and SH3 domain-containing protein 1, New molecule containing SH3 at the carboxy-terminus, Nesca
Application Note:
RUSC1 antibody can be used for detection of RUSC1 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Background:
RUSC1 Antibody: RUSC1, also known as NESCA, shares with the related protein RUSC2 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30% amino acid identity. RUSC1 is an adapter protein that can bind to the TrkA receptor and is necessary in the NGF-induced neurite growth of PC12 cells. RUSC1 has also been shown to interact with IκB kinase- (IKK-) gamma, the regulatory subunit of the IKK complex that is required for NF-κB activation in many signaling pathways such as TNF-R or the TLR pathways. RUSC1 can also bind to the E3 ubiquitin ligase TRAF6, which then catalyzes RUSC1 polyubiquitination. Since overexpression of RUSC1 strongly inhibits TRAF6-mediated polyubiquitination of IKK-gamma, RUSC1 may be a link in the IKK-gamma-mediated NF-κB activation pathway.
Background References:
- Matsuda S, Miyazaki K, Ichigotani Y, et al. Molecular cloning and characterization of a novel human gene (NESCA) which encodes a putative adapter protein containing SH3. Biochim. Biophys. Acta2000; 1491:321-6.
- Katoh M and Katoh M. Characterization of RUSC1 and RUSC2 genes in silico. Oncol. Rep.2004; 12:933-8.
- MacDonald JI, Kubu CJ, and Meakin SO. Nesca, a novel adapter, translocates to the nuclear envelope and regulates neurotrophin-induced neurite outgrowth. J. Cell Biol.2004; 164:851-62.
- Napolitano G, Mirra S, Monfregola J, et al. NESCA: a new NEMO/IKKgamma and TRAF6 interacting protein. J. Cell. Phys.2009; 220:410-7.
Buffer:
RUSC1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
RUSC1 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human RUSC1.
The immunogen is located within amino acids 780 - 830 of RUSC1.
The immunogen is located within amino acids 780 - 830 of RUSC1.
NCBI Gene ID #:
23623
NCBI Official Name:
RUN and SH3 domain containing 1
NCBI Official Symbol:
RUSC1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_001098673
Protein GI Number:
157412245
Purification:
RUSC1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Innate Immunity
Swissprot #:
Q9BVN2
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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