IA-1 Antibody
| Code | Size | Price |
|---|
| PSI-5415-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5415-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
IA-1 Antibody: IA1, IA-1, IA1, Insulinoma-associated protein 1, Zinc finger protein IA-1
Application Note:
IA-1 antibody can be used for detection of IA-1 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Background:
IA-1 Antibody: IA-1, also known as INSM1, is an essential five zinc-finger transcription factor that while initially identified from an insulinoma cDNA library, is expressed in the developing nervous system. Specifically, IA-1 is expressed as early as E9.5 in mice in the fore-, mid- and hindbrain, spinal cord, retina, and olfactory bulb. It is thought that IA-1 functions as a transcriptional repressor, and is a part of several signaling pathways including those of Notch and sonic hedgehog in addition to that of Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including the majority of neuroendocrine tumors tested so far as well as nearly 100% of all small cell lung carcinomas, indicating that IA-1 may be an important target in cancer therapy.
Background References:
- Lan MS, Li Q, Lu J, et al. Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1. J. Biol. Chem.1994; 269:14170-4.
- Jacob J, Storm R, Castro DS, et al. Insm (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain. Dev.2009; 136:2477-85.
- Breslin MB, Zhu M, and Lan MS. NeuroD1/E47 regulates the E-box element of a novel zinc-finger transcription factor, IA-1, in developing nervous system. J. Biol. Chem.2003; 278:38991-7.
- Nelson BR, Hartman BH, Georgi SA, et al. Transient inactivation of Notch signaling synchronizes differentiation of neural progenitor cells. Dev. Biol.2007; 304:479-98.
Buffer:
IA-1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Immunogen:
IA-1 antibody was raised against a 19 amino acid synthetic peptide from near the amino terminus of human IA-1.
The immunogen is located within amino acids 90 - 140 of IA-1.
The immunogen is located within amino acids 90 - 140 of IA-1.
NCBI Gene ID #:
3642
NCBI Official Name:
insulinoma-associated 1
NCBI Official Symbol:
INSM1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_002187
Protein GI Number:
4504713
Purification:
IA-1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer
Swissprot #:
Q01101
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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