SRPX2 Antibody

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ProSci
Product Code: PSI-5475
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-5475-0.02mg0.02mg£150.00
Quantity:
PSI-5475-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Images

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Western blot analysis of SRPX2 in human lung tissue lysate with SRPX2 antibody at (A) 1 and (B) 2 μg/mL.
2 / 3
Immunohistochemistry of SRPX2 in rat lung tissue with SRPX2 antibody at 5 μg/mL.
3 / 3
Immunofluorescence of SRPX2 in human lung tissue with SRPX2 antibody at 20 μg/mL.
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Western blot analysis of SRPX2 in human lung tissue lysate with SRPX2 antibody at (A) 1 and (B) 2 μg/mL.
Immunohistochemistry of SRPX2 in rat lung tissue with SRPX2 antibody at 5 μg/mL.
Immunofluorescence of SRPX2 in human lung tissue with SRPX2 antibody at 20 μg/mL.

Documents

Further Information

Additional Names:
SRPX2 Antibody: BPP, CBPS, PMGX, RESDX, SRPUL, Sushi repeat-containing protein SRPX2, Sushi-repeat protein upregulated in leukemia
Application Note:
SRPX2 antibody can be used for detection of SRPX2 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
SRPX2 Antibody: Sushi-repeat-containing protein X-linked 2 (SRPX2) is a neural gene functioning in the speech and language center of the human brain; mutations in this gene lead to epilepsy, speech dyspraxia, mental retardation and cognitive disorders. Recently, SRPX2 was found to be a novel mediator of angiogenesis and can act as a ligand for the urokinase-type plasminogen activator, a protein that can facilitate invasive migration of sprouting endothelial cells. SRPX2 is also overexpressed in gastric cancer, leading to increased phosphorylation levels of focal adhesion kinase and enhanced cellular migration and adhesion, suggesting that SRPX2 may be a potential target in the treatment of metastatic cancers.
Background References:
  • Roll P, Rudolf G, Pereira S, et al. SRPX2 mutations in disorders of language cortex and cognition. Hum. Mol. Genet.2006; 15:1195-207.
  • Miljkovic-Licina M, Hammel P, Garrido-Urbani S, et al. Sushi repeat protein X-linked 2, a novel mediator of angiogenesis. FASEB J.2009; 23:4105-16.
  • Blasi F and Carmeliet P. uPAR: a versatile signalling orchestrator. Nat. Rev. Mol. Cell. Biol.2002; 3:932-43.
  • Tanaka K, Arao T, Maegawa M, et al. SRPX2 is overexpressed in gastric cancer and promotes cellular migration and adhesion. Int. J. Cancer2009; 124:1072-80.
Buffer:
SRPX2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Immunogen:
SRPX2 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human SRPX2.

The immunogen is located within the first 50 amino acids of SRPX2.
NCBI Gene ID #:
27286
NCBI Official Name:
sushi-repeat-containing protein, X-linked 2
NCBI Official Symbol:
SRPX2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_055282
Protein GI Number:
7657619
Purification:
SRPX2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer
Swissprot #:
O60687
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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