PLEKHM2 Antibody
| Code | Size | Price |
|---|
| PSI-5485-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5485-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
PLEKHM2 Antibody: SKIP, KIAA0842, SKIP, Pleckstrin homology domain-containing family M member 2, Salmonella-induced filaments A and kinesin-interacting protein, PH domain-containing family M member 2
Application Note:
PLEKHM2 antibody can be used for detection of PLEKHM2 by Western blot at 0.5 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
PLEKHM2 Antibody: PLEKHM2, also known as SKIP, is a member of the M family of Pleckstrin homology domain-containing proteins. While little is known of PLEKHM2, a recent study examining differential gene expression in human hematopoietic stem cells has shown it to be specifically expressed in stem cells, suggesting that PLEKHM2 may play a role in erythroid commitment and development. Other studies have shown that PLEKHM2 is required for interaction with the Salmonella virulence factor SifA for Salmonella pathogenesis, suggesting that PLEKHM2 has cellular roles other than in the developing embryo.
Background References:
- Liu X-L, Yuan J-Y, Zhang J-W, et al. Differential gene expression in human hematopoietic stem cells specified toward erythroid, megakaryotic, and granulocytic lineage. J. Leuk. Biol.2007; 82:986-1002.
- Diacovich L, Dumont A, Lafitte D, et al. Interaction between the SifA virulence factor and its host target SKIP is essential for Salmonella pathogenesis. J. Biol. Chem.2009; 284:33151-60.
Buffer:
PLEKHM2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
PLEKHM2 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human PLEKHM2.
The immunogen is located within the last 50 amino acids of PLEKHM2.
The immunogen is located within the last 50 amino acids of PLEKHM2.
NCBI Gene ID #:
23207
NCBI Official Name:
pleckstrin homology domain containing, family M (with RUN domain) member 2
NCBI Official Symbol:
PLEKHM2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
CAH72018
Protein GI Number:
55666400
Purification:
PLEKHM2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
Swissprot #:
Q8IWE5
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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