MARVELD1 Antibody
| Code | Size | Price |
|---|
| PSI-5499-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5499-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
MARVELD1 Antibody: MRVLDC1, MARVEL domain-containing protein 1
Application Note:
MARVELD1 antibody can be used for detection of MARVELD1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Background:
MARVELD1 Antibody: MARVELD1, (MARVEL domain-containing 1), is one of the MARVEL (MAL and related proteins for vesicle trafficking and membrane link) domain-containing proteins. It is a nuclear-localized protein that is widely expressed in normal human tissues. While it has been reported to be overexpressed in colon cancer, MARVELD1 protein levels are generally lower in several primary tumors including ovary, breast, kidney, bladder and liver. This lower level of MARVELD1 expression in tumors is thought to be due to a higher methylation status of the MARVELD1 promoter as treatment of MDA-MB-361 with 5-aza-2'-deoxycytidine restores MARVELD1 expression, suggesting that loss of MARVELD1 expression may contribute to tumorgenicity.
Background References:
- Wang S, Li Y, Han F, et al. On of MARVELD1, a novel nuclear protein that is down-regulated in multiple cancers and silenced by DNA methylation. Cancer Lett.2009; 282:77-86.
- Alves PM, Levy N, Stevenson BJ, et al. Identification of tumor-associated antigens by large scale analysis of genes expressed in human colorectal cancer. Cancer Immun.2008; 8:11.
- Hatada I, Fukasawa M, and Kimura M. Genome-wide profiling of promoter methylation in human. Oncogene2006; 25:3059-64.
Buffer:
MARVELD1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
MARVELD1 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human MARVELD1.
The immunogen is located within the first 50 amino acids of MARVELD1.
The immunogen is located within the first 50 amino acids of MARVELD1.
NCBI Gene ID #:
83742
NCBI Official Name:
MARVEL domain containing 1
NCBI Official Symbol:
MARVELD1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
EAW49903
Protein GI Number:
119570288
Purification:
MARVELD1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer
Swissprot #:
Q9BSK0
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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