SLFN12 Antibody
| Code | Size | Price |
|---|
| PSI-5539-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5539-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
SLFN12 Antibody: SLFN3, Schlafen family member 12
Application Note:
SLFN12 antibody can be used for detection of SLFN12 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
SLFN12 Antibody: Despite being first described several years ago, the roles of the Schlafen (SLFN) family of proteins remain largely unknown. The SLFN genes are preferentially expressed in lymphoid tissues and differentially regulated during thymocyte maturation. It is thought that many play roles in cell growth, hemopoietic cell differentiation, and T cell development and maturation. Most members contain at least one divergent AAA domain (AAA_4) that may play a role in ATP binding. Although also known as SLFN3, a Schlafen family member that may be a marker of T cell activation, human SLFN12 has relatively low homology to SLFN3 in other species. Loss of the SLFN12 gene due to deletion is associated with Kabuki syndrome, a multiple congenital anomaly syndrome, suggesting SLFN may play a role in this genetic condition.
Background References:
- Schwarz DA, Katamaya CD, and Hedrick SM. Schlafen, a new family of growth regulatory genes that affect thymocyte development. Immunity1998; 9:657-68.
- Bustos O, Naik S, Ayers G, et al. Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes and orthopoxvirus virulence. Gene2009; 447:1-11.
- Condamine T, Le Laduec J-B, Chiffoleau E, et al. Characterization of Schlafen-3 expression in effector and regulatory T cells. J. Leuk. Biol.2010; 87:1-6.
- Cusco I, del Campo M, Vilardell M, et al. Array-CGH in patients with Kabuki-like phenotype: Identification of two patients with complex rearrangements including 2q37 deletions and no other recurrent aberration. BMC Med. Gen.2008; 9:27.
Buffer:
SLFN12 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
SLFN12 antibody was raised against a 12 amino acid synthetic peptide from near the carboxy terminus human SLFN12.
The immunogen is located within the last 50 amino acids of SLFN12.
The immunogen is located within the last 50 amino acids of SLFN12.
NCBI Gene ID #:
55106
NCBI Official Name:
schlafen family member 12
NCBI Official Symbol:
SLFN12
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_060512
Protein GI Number:
157388955
Purification:
SLFN12 Antibody is affinity chromatography purified via peptide column.
Research Area:
Immunology
Swissprot #:
Q8IYM2
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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