TRESK Antibody
| Code | Size | Price |
|---|
| PSI-5557-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5557-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
TRESK Antibody: TRIK, MGR13, TRESK, TRESK2, K2p18.1, TRESK-2, TRIK, Potassium channel subfamily K member 18, TWIK-related individual potassium channel
Application Note:
TRESK antibody can be used for detection of TRESK by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Background:
TRESK Antibody: TRESK (TWIK-related spinal cord K+ channel) is a two-pore domain K+ channel that induces outward rectification and functions as a background K+ channel that is abundantly expressed in the spinal cord, thymus, spleen, and leukemic T-lymphocytes. TRESK is activated by increased cytoplasmic calcium concentration through calcineurin as well as by acetylcholine and histamine. It has been suggested that TRESK is linked to acute and chronic pain by activation of calcineurin. Other studies indicate that TRESK may play a role in the regulation of T-cell function and could be an excellent target to treat T-cell originated immune dysfunction.
Background References:
- Sano Y, Inamura K, Miyake A, et al. A novel two-pore K+ channel, TRESK, is localized in the spinal cord. J. Biol. Chem.2003; 278:27406-12.
- Han J and Kang D. TRESK channel as a potential target to treat T-cell mediated immune dysfunction. Biochem. Biophys. Res. Comm.2009; 390:1102-5.
- Czirjak G, Toth ZE, and Enyedi P. The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin. J. Biol. Chem.2004; 279:18550-8.
- Huang DY, Yu BW, and Fan QW. Roles of TRESK, a novel two-pore domain K+ channel, in pain pathway and general anesthesia. Neurosci. Bull.2008; 24:166-72.
Buffer:
TRESK Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
TRESK antibody was raised against a 17 amino acid synthetic peptide from near the center of human TRESK.
The immunogen is located within amino acids 210 - 260 of TRESK.
The immunogen is located within amino acids 210 - 260 of TRESK.
NCBI Gene ID #:
338567
NCBI Official Name:
potassium channel, subfamily K, member 18
NCBI Official Symbol:
KCNK18
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_862823
Protein GI Number:
32469495
Purification:
TRESK Antibody is affinity chromatography purified via peptide column.
Research Area:
Immunology
Swissprot #:
Q7Z418
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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