LXR-B Antibody
| Code | Size | Price |
|---|
| PSI-5579-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5579-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
LXR-B Antibody: NER, UNR, LXRB, LXR-b, NER-I, RIP15, NER, Oxysterols receptor LXR-beta, Liver X receptor beta
Application Note:
LXR-B antibody can be used for detection of LXR-B by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
LXR-B Antibody: LXR-B belongs to the Liver X Receptor family that encodes highly homologous transcription factors. Like the highly homologous LXR-A, LXR-B forms heterodimers with the retinoic acid receptor RXRalpha, which function as sensors for cellular oxysterols which when activated, increase the expression of genes that control sterol and fatty acid metabolism and homeostasis. Recent experiments have indicated that the LXRs can also modulate both innate and adaptive immune responses. Other studies suggest that genetic variability at the LXR-B gene locus may be a risk factor for Alzheimer's disease. One hypothesis postulates that LXR may be upstream of ApoE and potentiates the risk associated effects of the epsilon3 allele.
Background References:
- Willy PJ, Umesono K, Ong ES, et al. LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev.1995; 9:1033-45.
- Edwards PA, Kennedy MA, and Mak PA. LXRs; Oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis. Vasc. Pharmacol.2002; 38:249-56.
- Bensinger SJ and Tontonoz P. Integration of metabolism and inflammation by lipid-activated nuclear receptors. Nature2008; 454:470-7.
- Adighibe O, Arepalli S, Duckworth J, et al. Genetic variability at the LXR gene (NR1H2) may contribute to the risk of Alzheimer's disease. Nerobiol. Aging2006; 27:1431-4.
Buffer:
LXR-B Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
LXR-B antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus human LXR-B.
The immunogen is located within the first 50 amino acids of LXR-B.
The immunogen is located within the first 50 amino acids of LXR-B.
NCBI Gene ID #:
7376
NCBI Official Name:
nuclear receptor subfamily 1, group H, member 2
NCBI Official Symbol:
NR1H2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
P55055
Protein GI Number:
1709254
Purification:
LXR-B Antibody is affinity chromatography purified via peptide column.
Research Area:
Innate Immunity
Swissprot #:
P55055
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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