CALHM1 Antibody
| Code | Size | Price |
|---|
| PSI-5593-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5593-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
CALHM1 Antibody: FAM26C, FAM26C, Calcium homeostasis modulator protein 1, Protein FAM26C
Application Note:
CALHM1 antibody can be used for detection of CALHM1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Background:
CALHM1 Antibody: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a massive loss of neurons in several brain regions and by the presence of senile plaques comprised of aggregated amyloid-beta (Abeta) peptides produced by the endoproteolysis of the amyloid precursor protein (APP). The calcium homeostasis modulator 1 (CALHM1) is a recently identified multipass transmembrane glycoprotein that controls cytosolic Ca2+ concentration and Abeta levels. While some studies suggest CALHM1 is significantly associated with risk of AD, other reports suggest there is no link. CALHM1 has been suggested to modulate the Ca2+-dependent proteolytic process of APP through controlling the level of cytosolic Ca2+.
Background References:
- Mattson MP. Pathways towards and away from Alzheimer's disease. Nature2004; 430:631-9.
- Dreses-Werringloer U, Lambert JC, Vingtdeux V, et al. A polymorphism in CALHM1 influences Ca2+ homeostasis, Ab levels, and Alzheimer 's disease risk. Cell2008; 133:1149-61.
- Nacmias B, Tedde A, Bagnoli S, et al. Lack of implication for CALHM1 P86L common variation in Italian patients with early and late onset Alzheimer 's disease. J. Alzheimers Dis.2010; epub.
Buffer:
CALHM1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
CALHM1 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human CALHM1.
The immunogen is located within amino acids 60 - 110 of CALHM1.
The immunogen is located within amino acids 60 - 110 of CALHM1.
NCBI Gene ID #:
255022
NCBI Official Name:
calcium homeostasis modulator 1
NCBI Official Symbol:
CALHM1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_001001412
Protein GI Number:
194440685
Purification:
CALHM1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Neuroscience
Swissprot #:
Q8IU99
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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