LZTR2 Antibody
| Code | Size | Price |
|---|
| PSI-5623-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5623-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
LZTR2 Antibody: RGPR, LZTR2, SEC16S, PGPR-p117, KIAA1928, RGPR, Protein transport protein Sec16B, Leucine zipper transcription regulator 2, RGPR-p117
Application Note:
LZTR2 antibody can be used for detection of LZTR2 by Western blot at 0.5 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Background:
LZTR2 Antibody: LZTR2, also known as RGPR-p117, is a member of the BTB-kelch superfamily and was initially described as a nuclear factor I (NFI) binding protein and transcriptional regulator of the regucalcin gene. LZTR2 is cytoplasmically localized but is thought to translocate to the nucleus, a process mediated by protein kinase C signaling following hormonal stimulation. Recent evidence has suggested that there is a strong correlation of single nucleotide polymorphisms of LZTR2 with obesity in the Japanese population similar to that seen with the TMEM18 gene and the GNPDA2, BDNF, FAIM2, and MC4R genes with obesity in Caucasian populations, suggesting LZTR2 may play a role in metabolism and obesity risk.
Background References:
- Misawa H and Yamaguchi M. Molecular cloning and sequencing of the cDNA coding for a novel regucalcin gene promoter region-related protein in rat, mouse and human liver. Int. J. Mol. Med.2001; 8:513-20.
- Yamaguchi M. Novel protein RGPR-p117: its role as the regucalcin gene transcription factor. Mol. Cell. Biochem.2009; 327:53-63.
- Hotta K, Nakamura M, Nakamura T, et al. Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. J. Hum. Genet.2009; 54:727-31.
Buffer:
LZTR2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (100%), Rabbit: (94%)
Immunogen:
LZTR2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human LZTR2.
The immunogen is located within the last 50 amino acids of LZTR2.
The immunogen is located within the last 50 amino acids of LZTR2.
NCBI Gene ID #:
89866
NCBI Official Name:
SEC16 homolog B (S. cerevisiae)
NCBI Official Symbol:
SEC16B
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_149118
Protein GI Number:
116235480
Purification:
LZTR2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Obesity
Swissprot #:
Q96JE7
User NOte:
Optimal dilutions for each application to be determined by the researcher.
Related Products
| Product Name | Product Code | Supplier | LZTR2 Peptide | PSI-5623P | ProSci | Summary Details | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|