BCAS3 Antibody
| Code | Size | Price |
|---|
| PSI-5629-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5629-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
BCAS3 Antibody: MAAB, GAOB1, Breast carcinoma-amplified sequence 3
Application Note:
BCAS3 antibody can be used for detection of BCAS3 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
BCAS3 Antibody: The Breast carcinoma amplified sequence (BCAS3) gene is localized to 17q23, a region that is often amplified in breast cancers. Copy number gains at this region have also been reported in other tumors such as brain, lung, liver, testis and bladder. BCAS3 is thought to be an estrogen receptor (ER)-alpha co-activator that acts through PELP1, another ER-alpha that in turn activates BCAS3 expression. This may set up a positive feedback loop leading to ER-a signal amplification in the cell which may play a significant role in breast cancer. BCAS3 expression has also been observed in embryonic stem cells and vascular precursors, suggesting that it may also play a role in embryogenesis and tumor angiogenesis.
Background References:
- Barlund M, Monni O, Weaver JD, et al. Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer. Genes Chromosomes Cancer2002; 35:311-7.
- Sinclair CS, Rowley M, Naderi A, et al. The 17q23 amplicon and breast cancer. Breast Cancer Res. Treat.2003; 78:313-22.
- Gururaj AE, Peng S, Vadlamudi RK, et al. Estrogen induces expression of BCAS3, a novel estrogen receptor-a coactivator, through Proline-, Glutamic acid-, and leucine-rich protein -1 (PELP1). Mol. Endocrinol.2007; 21:1847-60.
- Siva K, Venu P, Mahadevan A, et al. Human BCAS3 expression in embryonic stem cells and vascular precursors suggests a role,in human ebryogenesis and tumor angiogenesis. PloS One2007; 11:e1202.
Buffer:
BCAS3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
BCAS3 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human BCAS3.
The immunogen is located within amino acids 50 - 100 of BCAS3.
The immunogen is located within amino acids 50 - 100 of BCAS3.
NCBI Gene ID #:
54828
NCBI Official Name:
breast carcinoma amplified sequence 3
NCBI Official Symbol:
BCAS3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
EAW51415
Protein GI Number:
119571800
Purification:
BCAS3 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
Swissprot #:
Q9H6U6
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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