MYBPC2 Antibody
| Code | Size | Price |
|---|
| PSI-5651-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5651-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
MYBPC2 Antibody: MYBPC, MYBPCF, Myosin-binding protein C, fast-type, C-protein, skeletal muscle fast isoform, Fast MyBP-C
Application Note:
MYBPC2 antibody can be used for detection of MYBPC2 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.
Background:
MYBPC2 Antibody: Myosin binding protein C (MYBPC) is a component of the thick filament of striated muscle, with the fast-type isoform designated MYBPC2. Both the fast-type and slow-type MYBPC protein contains seven immunoglobulin C2 motifs and three fibronectin type-III repeats. MYBPC2 is typically required for strong contractions and functions under anaerobic conditions. It is more similar to the cardiac isoform (MYBPC3) than to the slow-type isoform (MYBPC1) in terms of pCa50-indexed force development, length-independent cooperativity and length dependent activation. It has been suggested that in cardiac and fast muscle MYBPC2 contributes to an internal load, possibly by binding to actin via its N-terminal region.
Background References:
- Weber FE, Vaughan KT, Reiach FC, et al. Complete sequence of human fast-type and slow-type muscle myosin-binding-protein C (MyBP-C). Differential expression, conserved domain structure and chromosome assignment. Eur. J. Biochem.1993; 216:661-9.
- Konhilas JP, Irving TC and De Tombe PP. Length-dependent activation in three striated muscle types of the rat. J. Physiol.2002; 544:225-36.
- Flashman E, Korkie L, Watkins H, et al. Support for a trimeric collar of myosin binding protein C in cardiac and fast skeletal muscle, but not in slow skeletal muscle. FEBS Lett.2008; 582:434-8.
Buffer:
MYBPC2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Chicken: (91%)
Immunogen:
MYBPC2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human MYBPC2.
The immunogen is located within amino acids 1070 - 1120 of MYBPC2.
The immunogen is located within amino acids 1070 - 1120 of MYBPC2.
NCBI Gene ID #:
4606
NCBI Official Name:
myosin binding protein C, fast type
NCBI Official Symbol:
MYBPC2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
EAW71866
Protein GI Number:
119592272
Purification:
MYBPC2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
Swissprot #:
Q14324
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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