NSA1 Antibody
| Code | Size | Price |
|---|
| PSI-5671-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5671-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
NSA1 Antibody: NSA1, WD repeat-containing protein 74, NOP seven-associated protein 1
Application Note:
NSA1 antibody can be used for detection of NSA1 by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Background:
NSA1 Antibody: The yeast nucleolar protein NOP7 is necessary for the maturation of 66S preribosomes and interacts with numerous other proteins. One such protein is an essential, conserved WD repeat protein, NOP seven-associated protein 1 (NSA1), that is also required for the yeast 66S ribosome assembly. NSA1 is also associated with the AAA ATPase Rix7, and release of NSA1 from a novel late nucleolar pre-60S requires the Rix7 function. NSA1 has also been found upregulated in mammalian cancer cells, suggesting it may also play a role in cell proliferation.
Background References:
- Miles TD, Jakovljevic J, Horsey EW, et al. Ytm1, Nop7, and Erb1 form a complex necessary for maturation of yeast 66S preribosomes. Mol. Cell Biol.2005; 25:10419-32.
- Harnpicharnchai P, Jakovljevic J, Horsey E, et al. Composition and functional characterization of yeast 66S ribosome assembly intermediates. Mol. Cell2001; 8:505-15.
- Kressler D, Roser D, Pertschy B, et al. The AAA ATPase Rix7 powers progression of ribosome biogenesis by stripping Nsa1 from pre-60S particles. J. Cell Biol.2008; 181:935-44.
- Krol M, Polanska J, Pawlowski KM, et al. Transcriptomic signature of cell lines isolated from canine mammary adenocarcinoma metastases to lungs. J. Appl. Genet.2010; 51:37-50.
Buffer:
NSA1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (79%)
Immunogen:
NSA1 antibody was raised against a 18 amino acid synthetic peptide near the amino terminus of human NSA1.
The immunogen is located within amino acids 90 - 140 of NSA1.
The immunogen is located within amino acids 90 - 140 of NSA1.
NCBI Gene ID #:
54663
NCBI Official Name:
WD repeat domain 74
NCBI Official Symbol:
WDR74
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
Q6RFH5
Protein GI Number:
55976441
Purification:
NSA1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
Swissprot #:
Q6RFH5
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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