ZC3H12B Antibody
| Code | Size | Price |
|---|
| PSI-5675-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5675-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
ZC3H12B Antibody: MCPIP2, CXorf32, MCPIP2, Probable ribonuclease ZC3H12B, MCP-induced protein 2
Application Note:
ZC3H12B antibody can be used for detection of ZC3H12B by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Background:
ZC3H12B Antibody: ZC3H12B, also known as MCPIP2, is a member of a family of novel CCCH-zinc finger proteins that regulate macrophage activation and may be involved in host immunity and inflammatory diseases. The function of ZC3H12B is not well understood. Unlike other members of the ZC3H12 family, ZC3H12B has a RasGEF domain at the C-terminal of the zinc finger motif, suggesting its potential involvement in Ras-mediated signal transduction. It is highly expressed in brain, thymus, and testis, but unlike ZC3H12A and ZC3H12C, not expressed in macrophages after treatment with lipopolysaccharide (LPS).
Background References:
- Zhou L, Azfer A, Niu J, et al. Monocyte chemoattractant protein-1 induces a novel transcription factor that causes cardiac myocyte apoptosis and ventricular dysfunction. Circ. Res.2006; 98:1177-85.
- Liang J, Wang J, Azfer A, et al. A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages. J. Biol. Chem.2008; 283:6337-46.
Buffer:
ZC3H12B Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
ZC3H12B antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human ZC3H12B.
The immunogen is located within the first 50 amino acids of ZC3H12B.
The immunogen is located within the first 50 amino acids of ZC3H12B.
NCBI Gene ID #:
340554
NCBI Official Name:
zinc finger CCCH-type containing 12B
NCBI Official Symbol:
ZC3H12B
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_001010888
Protein GI Number:
148746187
Purification:
ZC3H12B Antibody is affinity chromatography purified via peptide column.
Research Area:
Innate Immunity
Swissprot #:
Q5HYM0
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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