TMEM184C Antibody
| Code | Size | Price |
|---|
| PSI-5685-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5685-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
TMEM184C Antibody: TMEM34, TMEM34, PRO1355, Transmembrane protein 184C, Transmembrane protein 34
Application Note:
TMEM184C antibody can be used for detection of TMEM184C by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Background:
TMEM184C Antibody: Anaplastic thyroid cancer is one of the most lethal forms of cancer, but the precise carcinogenic mechanism has not been identified. TMEM184C, also known as TMEM34, was identified in a cDNA microarray analysis as being down-regulated in anaplastic thyroid cancers compared to normal thyroid tissues. TMEM184C protein expression was also lower in cell lines derived from these types of cancers compared to that of normal thyroid tissues or cell lines based on other types of thyroid cancers. Furthermore, transfection of TMEM34 into KTA2 cells led to the inhibition of cell growth, suggesting that TMEM184C might act as a tumor suppressor in anaplastic thyroid cancers.
Background References:
- Akaishi J, Onda M, Okamoto J, et al. Down-regulation of an inhibitor of cell growth, transmembrane protein 34 (TMEM34), in anaplastic thyroid cancer. J. Cancer Res. Clin. Oncol.2007; 133:213-8.
Buffer:
TMEM184C Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (87%)
Immunogen:
TMEM184C antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human TMEM184C.
The immunogen is located within amino acids 340 - 390 of TMEM184C.
The immunogen is located within amino acids 340 - 390 of TMEM184C.
NCBI Gene ID #:
55751
NCBI Official Name:
transmembrane protein 184C
NCBI Official Symbol:
TMEM184C
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_060711
Protein GI Number:
190358512
Purification:
TMEM184C Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
Swissprot #:
Q9NVA4
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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