Swine H1N1 Nucleocapsid Protein Antibody
| Code | Size | Price |
|---|
| PSI-5715-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5715-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
Documents
Further Information
Additional Names:
Swine H1N1 Nucleocapsid Protein Antibody:
Application Note:
NP antibody can be used for the detection of the NP protein from the H1N1 strain of swine-origin Influenza A in ELISA. For immunofluorescence start at 20 μg/mL.
Background:
Swine H1N1 Nucleocapsid Protein Antibody: Influenza A virus is a major public health threat, killing more than 30, 000 people per year in the USA. In early 2009, a novel swine-origin influenza A (H1N1) virus (S-OIV) was identified in specimens obtained from patients in Mexico and the United States. The influenza A virus polymerase transcribes and replicates eight virion RNA (vRNA) segments, among which the nucleocapsid protein (NP), thought to control whether mRNA or cRNA is produced. The nucleoprotein (NP), which has multiple functions during the virus life cycle, possesses regions that are highly conserved among influenza A, B, and C viruses. It was recently found several NP mutations that affected the efficient incorporation of multiple viral-RNA (vRNA) segments into progeny virions even though a single vRNA segment was incorporated efficiently. This indicates that the respective conserved amino acids in NP may be critical for the assembly and/or incorporation of sets of eight vRNA segments.
Background References:
- Thompson WW, Shay DK, Weintraub, et al. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA2003; 289:179-186.
- Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team, Dawood FS, Jain S, et al. Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N. Engl. J. Med.2009; 360:2605-15.
- Li Z, Watanabe T, Hatta M, et al. Mutational analysis of conserved amino acids in the influenza A virus nucleoprotein. J. Virol.2009; 83:4153-62.
- Newcomb LL, Kuo RL, Ye Q, et al. Interaction of the influenza a virus nucleocapsid protein with the viral RNA polymerase potentiates unprimed viral RNA replication. J. Virol.2009; 83:29-36.
Buffer:
Swine H1N1 Nucleocapsid Protein Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
NP antibody was raised against a synthetic peptide from the swine-Origin H1N1 NP protein.
The immunogen is located within amino acids 350 - 400 of Swine H1N1 Nucleocapsid Protein.
The immunogen is located within amino acids 350 - 400 of Swine H1N1 Nucleocapsid Protein.
NCBI Official Name:
nucleocapsid protein
NCBI Official Symbol:
NP
NCBI Organism:
Influenza A virus (A/California/14/2009(H1N1))
Physical State:
Liquid
Protein Accession #:
ACQ76305
Protein GI Number:
229535818
Purification:
Swine H1N1 Nucleocapsid Protein Antibody is affinity chromatography purified via peptide column.
Research Area:
Infectious Disease
SPECIFICITY:
This antibody is specific for the seasonal H1N1 influenza NP and will not recognize the corresponding NP from the seasonal H1N1 influenza (A/Brisbane/97/2007 (H1N1)).
Swissprot #:
C4AL25
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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