SIRT4 Antibody
| Code | Size | Price |
|---|
| PSI-5769-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5769-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Chicken
Antibody Isotype: IgY
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
SIRT4 Antibody: SIR2L4, SIR2L4, NAD-dependent protein deacetylase sirtuin-4, NAD-dependent ADP-ribosyltransferase sirtuin-4
Application Note:
SIRT4 antibody can be used for detection of SIRT4 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human and mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human and mouse samples. All other applications and species not yet tested.
Background:
SIRT4 Antibody: The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and have important functions in the regulation of metabolism, growth and differentiation, inflammation, cellular survival, as well as in senescence and lifespan extension. Sirtuins, including SIRT1-7, are human homologs of yeast Sir2p. Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) which regulate cellular metabolism, e.g. energy metabolism, and thereby are associated with aging and several age-related diseases. SIRT4 localizes to mitochondria, inhibits glutamate dehydrogenase, and is thought to be involved in the regulation of insulin secretion.
Background References:
- Salminen A. SIRT1: regulation of longevity via autophagy. Cell Signal2009; 21:1356-60.
- Afshar G and Murnane JP. Characterization of a human gene with sequence homology to Saccharomyces cerevisiae Sir 2. Gene1999; 234:161-8.
- Guarente L. Sirtuins as potential targets for metabolic syndrome. Nature2006; 444:868-74.
- Vaziri H, Dessain SK, Ng Eaton E, et al. hSIR2 (SIRT1) functions as an NAD-dependent p53 deacetylase. Cell2001; 107:149-59.
Buffer:
SIRT4 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Immunogen:
SIRT4 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human SIRT4.
The immunogen is located within amino acids 80 - 130 of SIRT4.
The immunogen is located within amino acids 80 - 130 of SIRT4.
NCBI Gene ID #:
23409
NCBI Official Name:
sirtuin 4
NCBI Official Symbol:
SIRT4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 37 kDa
Observed: 40 kDa
Observed: 40 kDa
Protein Accession #:
EAW98182
Protein GI Number:
119618588
Purification:
SIRT4 Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
Swissprot #:
Q9Y6E7
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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