SIRT6 Antibody
| Code | Size | Price |
|---|
| PSI-5773-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5773-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Chicken
Antibody Isotype: IgY
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
SIRT6 Antibody: SIR2L6, SIR2L6, NAD-dependent protein deacetylase sirtuin-6, Regulatory protein SIR2 homolog 6
Application Note:
SIRT6 antibody can be used for detection of SIRT6 by Western blot at 0.5 - 1 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
SIRT6 Antibody: The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and have important functions in the regulation of metabolism, growth and differentiation, inflammation, cellular survival, as well as in senescence and lifespan extension. Sirtuins, including SIRT1-7, are human homologs of yeast Sir2p. Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) which regulate cellular metabolism, e.g. energy metabolism, and thereby are associated with aging and several age-related diseases. SIRT6 is a histone H3 lysine 9 deacetylase and is thought to stabilize the DNA-dependent protein kinase at double-stranded DNA breaks and may have a role in the process of mammalian aging.
Background References:
- Salminen A. SIRT1: regulation of longevity via autophagy. Cell Signal2009; 21:1356-60.
- Afshar G and Murnane JP. Characterization of a human gene with sequence homology to Saccharomyces cerevisiae Sir 2. Gene1999; 234:161-8.
- Guarente L. Sirtuins as potential targets for metabolic syndrome. Nature2006; 444:868-74.
- Vaziri H, Dessain SK, Ng Eaton E, et al. hSIR2 (SIRT1) functions as an NAD-dependent p53 deacetylase. Cell2001; 107:149-59.
Buffer:
SIRT6 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
SIRT6 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human SIRT6.
The immunogen is located within the last 50 amino acids of SIRT6.
The immunogen is located within the last 50 amino acids of SIRT6.
NCBI Gene ID #:
51548
NCBI Official Name:
sirtuin 6
NCBI Official Symbol:
SIRT6
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
EAW69254
Protein GI Number:
119589660
Purification:
SIRT6 Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
Swissprot #:
Q8N6T7
User NOte:
Optimal dilutions for each application to be determined by the researcher.
Related Products
| Product Name | Product Code | Supplier | SIRT6 Peptide | PSI-5773P | ProSci | Summary Details | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|