SIRT7 Antibody
| Code | Size | Price |
|---|
| PSI-5775-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5775-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Chicken
Antibody Isotype: IgY
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
SIRT7 Antibody: SIR2L7, SIR2L7, NAD-dependent protein deacetylase sirtuin-7, Regulatory protein SIR2 homolog 7
Application Note:
SIRT7 antibody can be used for detection of SIRT7 by Western blot at 0.5 - 1 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
SIRT7 Antibody: The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and have important functions in the regulation of metabolism, growth and differentiation, inflammation, cellular survival, as well as in senescence and lifespan extension. Sirtuins, including SIRT1-7, are human homologs of yeast Sir2p. Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) which regulate cellular metabolism, e.g. energy metabolism, and thereby are associated with aging and several age-related diseases. SIRT7 is a nucleolar protein that positively regulates RNA polymerase I transcription and has been postulated to enable cells to sustain critical functions by inhibiting cell growth under severe stress conditions.
Background References:
- Salminen A. SIRT1: regulation of longevity via autophagy. Cell Signal2009; 21:1356-60.
- Afshar G and Murnane JP. Characterization of a human gene with sequence homology to Saccharomyces cerevisiae Sir 2. Gene1999; 234:161-8.
- Guarente L. Sirtuins as potential targets for metabolic syndrome. Nature2006; 444:868-74.
- Vaziri H, Dessain SK, Ng Eaton E, et al. hSIR2 (SIRT1) functions as an NAD-dependent p53 deacetylase. Cell2001; 107:149-59.
Buffer:
SIRT7 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Immunogen:
SIRT7 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human SIRT7.
The immunogen is located within amino acids 50 - 100 of SIRT7.
The immunogen is located within amino acids 50 - 100 of SIRT7.
NCBI Gene ID #:
51547
NCBI Official Name:
sirtuin 7
NCBI Official Symbol:
SIRT7
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_057622
Protein GI Number:
7706712
Purification:
SIRT7 Antibody is affinity chromatography purified via peptide column.
Research Area:
Homeostasis
Swissprot #:
Q9NRC8
User NOte:
Optimal dilutions for each application to be determined by the researcher.
Related Products
| Product Name | Product Code | Supplier | SIRT7 Peptide | PSI-5775P | ProSci | Summary Details | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|