TCTN2 Antibody
| Code | Size | Price |
|---|
| PSI-5835-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5835-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
TCTN2 Antibody: MKS8, TECT2, C12orf38, Tectonic-2
Application Note:
TCTN2 antibody can be used for detection of TCTN2 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
TCTN2 Antibody: TCTN2 is a member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. While the expression pattern and function of TCTN2 is not known, it is 49% similar to TCTN1. TCTN1 is expressed during embryonic development in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.
Background References:
- Reiter JF and Skarnes WC. Tectonic, a novel regulator of the Hedgehog pathwy required for both activation and inhibition. Genes Dev.2006; 20:22-7.
Buffer:
TCTN2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat: (75%)
Immunogen:
TCTN2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human TCTN2.
The immunogen is located within amino acids 610 - 660 of TCTN2.
The immunogen is located within amino acids 610 - 660 of TCTN2.
NCBI Gene ID #:
79867
NCBI Official Name:
tectonic family member 2
NCBI Official Symbol:
TCTN2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_079085
Protein GI Number:
31377681
Purification:
TCTN2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
Swissprot #:
Q96GX1
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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