IFITM1 Antibody
| Code | Size | Price |
|---|
| PSI-5805-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5805-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
IFITM1 Antibody: 9-27, CD225, IFI17, LEU13, DSPA2a, Interferon-induced transmembrane protein 1, Dispanin subfamily A member 2a
Application Note:
IFITM1 antibody can be used for detection of IFITM1 by Western blot at 2.5 - 5 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
IFITM1 Antibody: IFITM1 (Interferon inducible transmembrane protein 1) is a member of the IFN-inducible transmembrane protein family. It is an essential mediator of interferon-gamma-induced antiproliferation and plays a role in the control of cell growth. IFITM1 is upregulated in several tumor types and may be useful as a tumor biomarker. Both mouse IFITM1 and IFITM3 are expressed on the cell surfaces of primordial germ cells in a developmentally-regulated manner. IFITM1 activity is required for primordial germ cell transit, and IFITM1 acts as a repulsive molecule by repelling non-IFITM1-expressing primordial germ cells from the mesoderm into the endoderm.
Background References:
- Deblandre GA, Marinx OP, Evans SS, et al. Expression cloning of an interferon-inducible 17 kDa membrane protein implicated in the control of cell growth. J. Biol. Chem.1995; 270:23860-6.
- Yang G, Xu Y, Chen X, et al. IFITM1 plays an essential role in the antiproliferative action of interferon-gamma. Oncogene.2007; 26:594-603.
- Akyerli CB, Beksac M, Holko M, et al. Expression of IFITM1 in chronic myeloid leukemia patients. Leuk. Res.2005; 29:283-6.
- Tanaka SS, Yamaguchi YL, Tsoi B, et al. IFITM/Mil/Fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion. Cell 2005; 9:745-6.
Buffer:
IFITM1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
IFITM1 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human IFITM1.
The immunogen is located within the last 50 amino acids of IFITM1.
The immunogen is located within the last 50 amino acids of IFITM1.
NCBI Gene ID #:
8519
NCBI Official Name:
interferon induced transmembrane protein 1 (9-27)
NCBI Official Symbol:
IFITM1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_003632
Protein GI Number:
150010589
Purification:
IFITM1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
Swissprot #:
P13164
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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