IFITM1 Antibody

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ProSci
Product Code: PSI-5807
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-5807-0.02mg0.02mg£150.00
Quantity:
PSI-5807-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Images

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Western blot analysis of IFITM1 in 3T3 cell lysate with IFITM1 antibody at (A) 1 and (B) 2 μg/mL.
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Immunocytochemistry of IFITM1 in Jurkat cells with IFITM1 antibody at 20 μg/mL.
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Immunofluorescence of IFITM1 in Jurkat cells with IFITM1 antibody at 20 μg/mL.
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Western blot analysis of IFITM1 in 3T3 cell lysate with IFITM1 antibody at (A) 1 and (B) 2 μg/mL.
Immunocytochemistry of IFITM1 in Jurkat cells with IFITM1 antibody at 20 μg/mL.
Immunofluorescence of IFITM1 in Jurkat cells with IFITM1 antibody at 20 μg/mL.

Documents

Further Information

Additional Names:
IFITM1 Antibody: 9-27, CD225, IFI17, LEU13, DSPA2a, Interferon-induced transmembrane protein 1, Dispanin subfamily A member 2a
Application Note:
IFITM1 antibody can be used for detection of IFITM1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 20 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in mouse samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
IFITM1 Antibody: IFITM1 (Interferon inducible transmembrane protein 1) is a member of the IFN-inducible transmembrane protein family. It is an essential mediator of interferon-gamma-induced antiproliferation and plays a role in the control of cell growth. IFITM1 is upregulated in several tumor types and may be useful as a tumor biomarker. Both mouse IFITM1 and IFITM3 are expressed on the cell surfaces of primordial germ cells in a developmentally-regulated manner. IFITM1 activity is required for primordial germ cell transit, and IFITM1 acts as a repulsive molecule by repelling non-IFITM1-expressing primordial germ cells from the mesoderm into the endoderm.
Background References:
  • Deblandre GA, Marinx OP, Evans SS, et al. Expression cloning of an interferon-inducible 17 kDa membrane protein implicated in the control of cell growth. J. Biol. Chem. 1995; 270:23860-6.
  • Yang G, Xu Y, Chen X, et al. IFITM1 plays an essential role in the antiproliferative action of interferon-gamma. Oncogene. 2007; 26:594-603.
  • Akyerli CB, Beksac M, Holko M, et al. Expression of IFITM1 in chronic myeloid leukemia patients. Leuk. Res. 2005; 29:283-6.
  • Tanaka SS, Yamaguchi YL, Tsoi B, et al. IFITM/Mil/Fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion. Cell 2005; 9:745-6.
Buffer:
IFITM1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
IFITM1 antibody was raised against a 16 amino acid synthetic peptide near the center of human IFITM1.

The immunogen is located within amino acids 40 - 90 of IFITM1.
NCBI Gene ID #:
8519
NCBI Official Name:
interferon induced transmembrane protein 1 (9-27)
NCBI Official Symbol:
IFITM1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
Predicted: 14 kDa

Observed: 14 kDa
Protein Accession #:
NP_003632
Protein GI Number:
150010589
Purification:
IFITM1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Cancer,Cell Cycle
Swissprot #:
P13164
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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