SCUBE1 Antibody
| Code | Size | Price |
|---|
| PSI-5843-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5843-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
SCUBE1 Antibody: Signal peptide, CUB and EGF-like domain-containing protein 1
Application Note:
SCUBE1 antibody can be used for detection of SCUBE1 by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 20 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
SCUBE1 Antibody: SCUBE1 is an EGF-related protein with a CUB (C1s-like) domain that is expressed primarily in the developing gonad, nervous system, somites, surface ectoderm and limb buds. The N-terminal EGF-like repeats of SCUBE1 participate in the formation of adhesions in a Ca2+-dependent fashion. In contrast, the C-terminal cysteine-rich motifs and CUB domain can directly bind and antagonize bone morphogenic protein activity; genetic ablation of this region resulted in brain malformation in mice embryos, suggesting SCUBE1 plays a role in brain morphogenesis. SCUBE1 has also been implicated in early craniofacial development in mice.
Background References:
- Grimmond S, Larder R, Van Hateren N, et al. Cloning, mapping, and expression analysis of a gene encoding a novel mammalian EGF-related protein (SCUBE1). Genomics2000; 70:74-81.
- Tu C, Yan Y, Wu S, et al. Domain and function analysis of a novel platelet-endothelial cell surface protein, SCUBE1. J. Biol. Chem.2008; 283:12478-88.
- Xaiver GM, Sharpe PT, and Colbourne MT. Scube1 is expressed during facial development in the mouse. J. Exp. Zool. B. Mol. Dev. Evol.2009; 312B:518-24.
Buffer:
SCUBE1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (93%)
Immunogen:
SCUBE1 antibody was raised against a 14 amino acid synthetic peptide near the center of human SCUBE1.
The immunogen is located within amino acids 460 - 510 of SCUBE1.
The immunogen is located within amino acids 460 - 510 of SCUBE1.
NCBI Gene ID #:
80274
NCBI Official Name:
signal peptide, CUB domain, EGF-like 1
NCBI Official Symbol:
SCUBE1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_766638
Protein GI Number:
120587029
Purification:
SCUBE1 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
Swissprot #:
Q8IWY4
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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