CaBP7 Antibody

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ProSci
Product Code: PSI-5859
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-5859-0.02mg0.02mg£150.00
Quantity:
PSI-5859-0.1mg0.1mg£449.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Immunofluorescence (IF)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)

Images

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Western blot analysis of CaBP7 in Hela cell lysate with CaBP7 antibody at (A) 1 and (B) 2 μg/mL.
2 / 3
Immunocytochemistry of CaBP7 in HeLa cells with CaBP7 antibody at 4 μg/mL.
3 / 3
Immunofluorescence of CABP7 in HeLa cells with CAPB7 antibody at 20 μg/mL.
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Western blot analysis of CaBP7 in Hela cell lysate with CaBP7 antibody at (A) 1 and (B) 2 μg/mL.
Immunocytochemistry of CaBP7 in HeLa cells with CaBP7 antibody at 4 μg/mL.
Immunofluorescence of CABP7 in HeLa cells with CAPB7 antibody at 20 μg/mL.

Documents

Further Information

Additional Names:
CaBP7 Antibody: CALN2, CALN2, Calcium-binding protein 7, Calneuron II, CaBP7
Application Note:
CaBP7 antibody can be used for detection of CaBP7 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 4 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
CaBP7 Antibody: Calcium binding proteins (CaBP) play a crucial role in the calcium-mediated cellular signal transduction pathway in the central nervous system. The CaBP family shares much similarity with CaM I (calmodulin), and it has been shown that CaBP proteins can substitute functionally for, and possibly augment the function of, CaM I. CaBP7 (Calcium-binding protein 7), contains two EF-hand domains for calcium binding and shares 70% homology with CaBP8 and 50% homology with CaM I. It negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. CaBP7 and 8 possess a targeting mechanism that is unique amongst the CaBPs that may contribute to differential functional Ca2+-sensing by these family members.
Background References:
  • Sokal I, Li N, Verlinde CL, et al. Ca2+-binding proteins in the retina: from discovery to etiology of human disease. Biochim. Biophys. Acta.2000; 1498: 233-51.
  • Haeseleer F, Imanishi Y, Sokal I, et al. Calcium-binding proteins: intracellular sensors from the calmodulin superfamily. Biochem. Biophys. Res. Commun.2002; 290:615-23.
  • Ikura M, Osawa M, and Ames JB. The role of calcium-binding proteins in the control of transcription: structure to function. Bioessays2002; 24:625-36.
  • McCue HV, Burgoyne RD, Haynes LP. Membrane targeting of the EF-hand containing calcium-sensing proteins CaBP7 and CaBP8. Biochem. Biophys. Res. Commun.2009; 380:825-31.
Buffer:
CaBP7 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
CaBP7 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human CaBP7.

The immunogen is located within the first 50 amino acids of CaBP7.
NCBI Gene ID #:
164633
NCBI Official Name:
calcium binding protein 7
NCBI Official Symbol:
CABP7
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_872333
Protein GI Number:
32698884
Purification:
CaBP7 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
Swissprot #:
Q86V35
User NOte:
Optimal dilutions for each application to be determined by the researcher.

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