CaBP8 Antibody
| Code | Size | Price |
|---|
| PSI-5861-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5861-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
CaBP8 Antibody: CABP8, CABP8, Calcium-binding protein 8, Calneuron I, CaBP8
Application Note:
CaBP8 antibody can be used for detection of CaBP8 by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Background:
CaBP8 Antibody: Calcium binding proteins (CaBP) play a crucial role in the calcium-mediated cellular signal transduction pathway in the central nervous system. The CaBP family shares much similarity with CaM I (calmodulin), and it has been shown that CaBP proteins can substitute functionally for, and possibly augment the function of, CaM I. CaBP8, contains two EF-hand domains for calcium binding and shares 70% homology with CaBP7 and 50% homology with CaM I. It negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. Both CaBP8 and CaBP7 possess a targeting mechanism that is unique amongst the CaBPs that may contribute to differential functional Ca2+-sensing by these family members.
Background References:
- Sokal I, Li N, Verlinde CL, et al. Ca2+-binding proteins in the retina: from discovery to etiology of human disease. Biochim. Biophys. Acta.2000; 1498: 233-51.
- Haeseleer F, Imanishi Y, Sokal I, et al. Calcium-binding proteins: intracellular sensors from the calmodulin superfamily. Biochem. Biophys. Res. Commun.2002; 290:615-23.
- Ikura M, Osawa M, and Ames JB. The role of calcium-binding proteins in the control of transcription: structure to function. Bioessays2002; 24:625-36.
- McCue HV, Burgoyne RD, Haynes LP. Membrane targeting of the EF-hand containing calcium-sensing proteins CaBP7 and CaBP8. Biochem. Biophys. Res. Commun.2009; 380:825-31.
Buffer:
CaBP8 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
CaBP8 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CaBP8.
The immunogen is located within the first 50 amino acids of CaBP8.
The immunogen is located within the first 50 amino acids of CaBP8.
NCBI Gene ID #:
83698
NCBI Official Name:
calneuron 1
NCBI Official Symbol:
CALN1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_113656
Protein GI Number:
157743275
Purification:
CaBP8 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
Swissprot #:
Q9BXU9
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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