CCDC106 Antibody
| Code | Size | Price |
|---|
| PSI-5865-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5865-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
CCDC106 Antibody: ZNF581, HSU79303, Coiled-coil domain-containing protein 106
Application Note:
CCDC106 antibody can be used for detection of CCDC106 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Background:
CCDC106 Antibody: The coiled-coil domain is a common protein motif that is often involved in protein oligomerization and is found in proteins such as transcription factors and intermediate filaments. CCDC106 was initially identified as a p53-interacting protein by yeast two-hybrid screening. Other experiments demonstrated that CCDC106 co-localizes and interacts with p53 in the nucleus, inhibiting the transcriptional activity of p53 and stimulating p53 protein degradation, indicating that at least one of the functions of CCDC106 is acting as a negative regulator of p53.
Background References:
- Steinmetz MO, Jelesarov I, Matousek WM, et al. Molecular basis of coiled-coil formation. Proc. Natl. Acad. Sci. USA2007; 104:7062-7.
- telzl U, Worm U, Lalowski M, et al. A human protein-protein interaction network: a resource for annotating the proteome. Cell2005; 122:957-68.
- Zhou J, Qiao X, Xiao L, et al. Identification and characterization of the novel protein CCDC106 that interacts with p53 and promotes its degradation. FEBS Lett.2010; 584:1085-90.
Buffer:
CCDC106 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Immunogen:
CCDC106 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human CCDC106.
The immunogen is located within the last 50 amino acids of CCDC106.
The immunogen is located within the last 50 amino acids of CCDC106.
NCBI Gene ID #:
29903
NCBI Official Name:
coiled-coil domain containing 106
NCBI Official Symbol:
CCDC106
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_037433
Protein GI Number:
94536856
Purification:
CCDC106 Antibody is affinity chromatography purified via peptide column.
Research Area:
Signal Transduction
Swissprot #:
Q9BWC9
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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