VENTX Antibody
| Code | Size | Price |
|---|
| PSI-5863-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5863-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
VENTX Antibody: NA88A, HPX42B, VENTX2, Homeobox protein VENTX, VENT homeobox homolog
Application Note:
VENTX antibody can be used for detection of VENTX by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Background:
VENTX Antibody: Lymphoid-enhancing factor/T-cell factors (LEF1/TCF) are a high-mobility group of transcriptional factors that play essential roles in cell fate determination during early embryogenesis and ontogenesis. VENTX is a member of the Vent family of homeodomain proteins. It is a novel LEF/TCF-associated transcriptional modulator. VENTX is predominately expressed in hematopoietic cells. VENTX may function as a transcriptional repressor and be involved in mesodermal patterning and hemapoietic stem cell maintenance, and has been suggested to have a potential role in the hematopoietic malignancies.
Background References:
- Reya T and Clevers H. Wnt signalling in stem cells and cancer. Nature2005; 434:843-50.
- Moretti PA, Davidson AJ, Baker E, et al. Molecular cloning of a human Vent-like homeobox gene. Genomics2001; 76:21-9.
- Gao H, Le Y, Wu X, et al. VentX, a novel lymphoid-enhancing factor/T-cell factor-associated transcription repressor, is a putative tumor suppressor. Cancer Res.2010; 70:202-11.
- Shtutman M, Zhurinsky J, Simcha I, et al. The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway. Proc. Natl. Acad. Sci. USA1999; 96:5522-7.
Buffer:
VENTX Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (92%), Chicken: (92%)
Immunogen:
VENTX antibody was raised against a 16 amino acid synthetic peptide near the center of human VENTX.
The immunogen is located within amino acids 120 - 170 of VENTX.
The immunogen is located within amino acids 120 - 170 of VENTX.
NCBI Gene ID #:
27287
NCBI Official Name:
VENT homeobox homolog (Xenopus laevis)
NCBI Official Symbol:
VENTX
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_055283
Protein GI Number:
7657180
Purification:
VENTX Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
Swissprot #:
O95231
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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