WDR92 Antibody
| Code | Size | Price |
|---|
| PSI-5883-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5883-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
WDR92 Antibody: WD repeat-containing protein 92, WD repeat-containing protein Monad
Application Note:
WDR92 antibody can be used for detection of WDR92 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
WDR92 Antibody: WD40 repeats are a common structural module in eukaryotic proteins, and proteins containing WD40 domains have a wide range of functions, including signal transduction, cell cycle regulation, RNA splicing, and transcription. One such protein, WDR92, also known as monad, contains two WD40 repeats is widely expressed in human tissues, especially testis. Overexpression of this protein or its binding partner RNA polymerase II-associated protein 3 (RPAP3) potentiated apoptosis and caspase-3 activation induced by TNF-α and cycloheximide, suggesting that WDR92, together with RPAP3, may function as a novel modulator of apoptosis.
Background References:
- Saeki M, Irie Y, Ni L, et al. Monad, a WD40 repeat protein, promotes apoptosis induced by TNF-alpha. Biochem. Biophys. Res. Commun.2006; 342:568-72.
- Itsuki Y, Saeki M, Nakahara H, et al. Molecular cloning of novel Monad binding protein containing tetratricorticopeptide repeat domains. FEBS Lett.582:2365-70.
Buffer:
WDR92 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Immunogen:
WDR92 antibody was raised against a 21 amino acid synthetic peptide near the center of human WDR92.
The immunogen is located within amino acids 140 - 190 of WDR92.
The immunogen is located within amino acids 140 - 190 of WDR92.
NCBI Gene ID #:
116143
NCBI Official Name:
WD repeat domain 92
NCBI Official Symbol:
WDR92
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_612467
Protein GI Number:
24308444
Purification:
WDR92 Antibody is affinity chromatography purified via peptide column.
Research Area:
Apoptosis
Swissprot #:
Q96MX6
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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