YBX2 Antibody
| Code | Size | Price |
|---|
| PSI-5885-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5885-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Documents
Further Information
Additional Names:
YBX2 Antibody: DBPC, MSY2, CSDA3, CONTRIN, Y-box-binding protein 2, Contrin, Dbpc
Application Note:
YBX2 antibody can be used for detection of YBX2 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
YBX2 Antibody: Germ cell specific Y-box binding protein (YBX2), a germ-cell-specific member of the Y-box family of DNA-/RNA-binding proteins, is a major constituent of messenger ribonucleoprotein particles (mRNPs) and involved in the regulation of the stability and/or translation of germ cell mRNAs. It is proposed to function as a coactivator of transcription in the nucleus and to stabilize and store maternal and paternal mRNAs in the cytoplasm. YBX2 binds to the Y-box consensus promoter element and is expressed in oocytes and testicular germ cells in the stage of spermatogonia to spermatocyte. Recent studies show that deletion of YBX2 leads to the disruption of both spermatogenesis and oogenesis.
Background References:
- Kohno Y, Matsuki Y, Tanimoto A, et al. Expression of Y-box-binding protein dbpC/contrin, a potentially new cancer/testis antigen. Br. J. Cancer2006; 94:710-6.
- Medvedev S, Yang J, Hecht NB, et al. CDC2A (CDK1)-mediated phosphorylation of MSY2 triggers maternal mRNA degradation during mouse oocyte maturation. Dev. Biol.2008; 321:205-15.
- Yang J, Medvedev S, Yu J, et al. Absence of the DNA-/RNA-binding protein MSY2 results in male and female infertility. Proc. Natl. Acad. Sci. USA2005; 102:5755-60.
- Hammoud S, Emery BR, and Dunn D. Sequence alterations in the YBX2 gene are associated with male factor infertility. Fertil. Steril.2009; 91:1090-5.
Buffer:
YBX2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
YBX2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy end of human YBX2.
The immunogen is located within amino acids 300 - 350 of YBX2.
The immunogen is located within amino acids 300 - 350 of YBX2.
NCBI Gene ID #:
51087
NCBI Official Name:
Y box binding protein 2
NCBI Official Symbol:
YBX2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_057066
Protein GI Number:
156415990
Purification:
YBX2 Antibody is affinity chromatography purified via peptide column.
Research Area:
Stem Cell
Swissprot #:
Q9Y2T7
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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