NOD3 Antibody
| Code | Size | Price |
|---|
| PSI-5949-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5949-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Western Blot (WB)
Documents
Further Information
Additional Names:
NOD3 Antibody: NOD3, CLR16.2, NOD3, Protein NLRC3, CARD15-like protein
Application Note:
NOD3 antibody can be used for detection of NOD3 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunofluorescence starting at 20 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
NOD3 Antibody: NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-kappaB, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells.
Background References:
- Kufer TA, Banks DJ, and Philpott DJ. Innate immune sensing of microbes by Nod proteins. Ann. NY Acad. Sci.2006; 1072:19-27.
- Conti BJ, Davis BK, Zhang J, et al. CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function. J. Biol. Chem.2005; 280:18375-85.
Buffer:
NOD3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
NOD3 antibody was raised against an 18 amino acid synthetic peptide near the center of human NOD3.
The immunogen is located within amino acids 630 - 680 of NOD3.
The immunogen is located within amino acids 630 - 680 of NOD3.
NCBI Gene ID #:
197358
NCBI Official Name:
NLR family, CARD domain containing 3
NCBI Official Symbol:
NLRC3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
EAW85351
Protein GI Number:
119605757
Purification:
NOD3 Antibody is affinity chromatography purified via peptide column.
Research Area:
Innate Immunity
Swissprot #:
Q7RTR2
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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