NALP4 Antibody
| Code | Size | Price |
|---|
| PSI-5957-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5957-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Documents
Further Information
Additional Names:
NALP4 Antibody: CT58, PAN2, RNH2, NALP4, PYPAF4, CLR19.5, NACHT, LRR and PYD domains-containing protein 4, PAAD and NACHT-containing protein 2, CT58
Application Note:
NALP4 antibody can be used for detection of NALP4 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Background:
NALP4 Antibody: NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP4, also known as PYRIN-containing APAF1-like protein 4, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. In transfected 293 cells, NALP4 suppressed NF-κB induction by TNF-α and IL-1β, suggesting NALP4 operates at a point of convergence in these two signaling pathways. NALP4 also suppressed NF-κB induction resulting from overexpression of several adapter proteins and protein kinases involved in these pathways, including TRAF2, TRAF6, RIP, and IRAK2, as well as the IKK-alpha and IKK-beta, suggesting that NALP4 is critical in modulating NF-κB activity.
Background References:
- Tschopp J, Martinon F, and Burns K. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol.2003; 4:95-104.
- Tian X, Pascal G, and Monget P. Evolution and functional divergence of NLRP genes in mammalian reproductive system. BMC Evol. Biol.2009; 9:202.
- Fiortino L, Stehlik C, Oliveira V, et al. A novel PAAD-containing protein that modulates NF-kappa B induction by cytokines tumor necrosis factor-alpha and interleukin-1beta. J. Biol. Chem.2002; 277:35333-40.
Buffer:
NALP4 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
NALP4 antibody was raised against a 13 amino acid synthetic peptide near the center of human NALP4.
The immunogen is located within amino acids 330 - 380 of NALP4.
The immunogen is located within amino acids 330 - 380 of NALP4.
NCBI Gene ID #:
147945
NCBI Official Name:
NLR family, pyrin domain containing 4
NCBI Official Symbol:
NLRP4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
AAL35293
Protein GI Number:
17064172
Purification:
NALP4 Antibody is affinity chromatography purified via peptide column.
Research Area:
Innate Immunity
Swissprot #:
Q96MN2
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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