NALP6 Antibody
| Code | Size | Price |
|---|
| PSI-5961-0.02mg | 0.02mg | £150.00 |
Quantity:
| PSI-5961-0.1mg | 0.1mg | £449.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunofluorescence (IF)
- Western Blot (WB)
Documents
Further Information
Additional Names:
NALP6 Antibody: AVR, NAVR, PAN3, NALP6, PYPAF5, CLR11.4, NAVR/AVR, NACHT, LRR and PYD domains-containing protein 6, PYRIN-containing APAF1-like protein 5
Application Note:
NALP6 antibody can be used for detection of NALP6 by Western blot at 2 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Background:
NALP6 Antibody: NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP6, also known as PYPAF5, is highly expressed in granulocytes and T cells and co-localizes with the PYRIN-CARD protein ASC. Co-expression of NALP6 with ASC results in a synergistic activation of NF-κB and activated caspase-1-dependent cytokine processing, suggesting that NALP6 functions in immune cells to coordinate the transduction of pro-inflammatory signals.
Background References:
- Tschopp J, Martinon F, and Burns K. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol.2003; 4:95-104.
- Tian X, Pascal G, and Monget P. Evolution and functional divergence of NLRP genes in mammalian reproductive system. BMC Evol. Biol.2009; 9:202.
- Grenier JM, Wang L, Manji GA, et al. Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1. FEBS Lett.2002; 530:73-8.
Buffer:
NALP6 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (92%), Rat: (92%)
Immunogen:
NALP6 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human NALP6.
The immunogen is located within amino acids 150 - 200 of NALP6.
The immunogen is located within amino acids 150 - 200 of NALP6.
NCBI Gene ID #:
171389
NCBI Official Name:
NLR family, pyrin domain containing 6
NCBI Official Symbol:
NLRP6
NCBI Organism:
Homo sapiens
Physical State:
Liquid
Protein Accession #:
NP_612202
Protein GI Number:
21264320
Purification:
NALP6 Antibody is affinity chromatography purified via peptide column.
Research Area:
Innate Immunity
Swissprot #:
P59044
User NOte:
Optimal dilutions for each application to be determined by the researcher.
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